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. 2015 Oct 14;290(48):29035–29044. doi: 10.1074/jbc.M115.682310

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 5. — Loss of Atg7 in the RPE does not lead to age-associated retinal disease A, toluene blue staining of retinal sections from 12-month-old Atg7^flox/flox;cre+ and Atg7^flox/flox;cre- mice. OS, outer segment; IS, inner segment; ONL, outer nuclear layer; OPL, outer plexiform layer; INL, inner nuclear layer; IPL, inner plexiform layer; GCL, ganglion cell layer. Scale bar 50 μm. B, outer nuclear layer (ONL) thickness was measured on DAPI stained retinal sections from 12-month-old Atg7^flox/flox;cre+ and Atg7^flox/flox;cre- mice, n = 4 animals per group. Error bars indicate the mean ± S.D. ONH, optic nerve head. C and D, electron microscopic images displaying dysfunctional autophagy in the RPE of Atg7^flox/flox;cre+ mice, including partial digestion of melanosomes (C) and rod outer segments (D). Scale bar 1 μm.