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Influence of CDR3β on the conformation of CDR3α in TCR C7. Conformation of CDR3α and CDR3β loops in superposed C7·NLV·HLA-A2 and RA14·NLV·HLA-A2 complexes (pink, TCR C7; cyan, C7-bound NLV·HLA-A2; green, TCR RA14; orange, RA14-bound NLV·HLA-A2). In RA14, but not in C7, the tip of CDR3β points toward CDR3α, resulting in interactions that draw CDR3α close to CDR3β in RA14. These interactions are absent in C7, whose CDR3β sequence (SQTQLWETQ) is unrelated to that of RA14 (SPVTGGIYGY).
