. 2015 Nov 27;2:84. doi: 10.3389/fmed.2015.00084

Table 5.

Two-compartment population analysis of IMP288 pharmacokinetics.

Parameter^a	k_2,1 (h⁻¹)	k_1,2 (h⁻¹)	A_S	B_S	MR	k_el (h⁻¹)	Volume/m² (L/m²)	Vc (L)	Clearance (L/h)
Population values
Estimation	0.027	0.019	1.42	0.182	NA	NA	6.38	NA	NA
SD	0.001	0.002	0.07	0.012	NA	NA	0.27	NA	NA
Individual values
Patient 1, indium	0.027	0.021	1.35	0.169	124.2	0.226	6.69	13.4	3.04
Patient 1, lutetium	0.024	0.021	1.37	0.172	125.5	0.241	6.50	13.1	3.15
Patient 2, indium	0.026	0.023	1.31	0.167	40.7	0.250	6.54	9.7	2.43
Patient 2, lutetium	0.027	0.022	1.22	0.156	40.1	0.219	6.63	9.9	2.16
Patient 3, indium	0.028	0.015	1.53	0.199	35.7	0.185	6.23	16.8	3.11
Patient 3, lutetium	0.028	0.017	1.43	0.183	37.8	0.165	6.25	16.8	2.78
Patient 4, indium	0.026	0.026	0.92	0.141	22.6	0.112	6.90	12.7	1.43
Patient 4, lutetium	0.029	0.019	1.29	0.167	22.0	0.173	6.78	12.5	2.17
Patient 5, indium	0.027	0.017	1.53	0.196	22.5	0.235	6.15	12.0	2.82
Patient 5, lutetium	0.028	0.017	1.52	0.196	31.1	0.249	6.13	11.9	2.97
Patient 6, indium	0.027	0.019	1.41	0.179	109.0	0.291	6.44	11.2	3.25
Patient 6, lutetium	0.028	0.021	1.31	0.170	18.8	0.179	6.93	12.0	2.15
Patient 7, indium	0.027	0.022	1.41	0.181	3.3	0.146	6.21	12.0	1.76
Patient 7, lutetium	0.028	0.018	1.41	0.181	3.2	0.137	6.54	12.7	1.74
Patient 8, indium	0.028	0.018	1.44	0.182	2.3	0.161	6.18	10.4	1.68
Patient 8, lutetium	0.028	0.020	1.16	0.174	2.5	0.124	6.49	10.9	1.36
Mean^b	0.027	0.020	1.35	0.176		0.193	6.47	12.4	2.37
SD	0.001	0.003	0.16	0.015		0.052	0.27	2.0	0.65
CV (%)	4.5	14.3	11.5	8.6		27.0	4.1	16.4	27.5

^aThe transfer rates (k_2,1 and k_1,2), the central compartment volume per body surface area unit (m²), and the two parameters A and B were adjusted using a two-compartment model. Estimations of the population adjusted parameters are given together with their estimated SD. The central compartment volume was a dependent parameter (Vc = volume/m² × patient body surface area). Clearance was calculated as A_S × MR^BS, MR being the ratio of the number of moles of injected IMP288 to the number of moles of TF2 present in the circulation at the time of IMP288 injection and the elimination constant k_el as clearance/Vc.

^bThe mean, SD, and CV for each parameters were calculated from individual estimations.