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. 2015 Nov 27;5:17149. doi: 10.1038/srep17149

Table 2. Summary ORs and 95% CI of IL-10 −1082A > G and −819T > C and −592A > C polymorphisms and head and neck cancer risk.

−1082 A>G N* G vs. A
 AG vs. AA
 GG vs. AA
 AG + GG vs. AA
 GG vs. AA + AG
  
OR 95% CI P I2 OR 95% CI P I2 OR 95% CI P I2 OR 95% CI P I2 OR 95% CI P I2  
Total 9 1.56 1.27–1.92 <0.01 69.4 1.64 1.32–2.05 <0.01 55.6 2.24 1.69–2.97 <0.01 38.5 1.70 1.36–2.14 <0.01 61.8 1.89 1.23–2.90 0.01 46.3  
HWE-yes 3 1.05 0.81–1.37 0.71 0 0.99 0.71–1.38 0.95 0 1.29 0.64–2.58 0.49 0 1.02 0.74–1.41 0.88 0 1.18 0.63–2.22 0.60 0  
HWE-no 6 1.82 1.51–2.19 <0.01 54.4 1.94 1.67–2.25 <0.01 0 2.54 1.57–4.12 <0.01 48.0 2.04 1.77–2.35 <0.01 0.4 2.12 1.24–3.60 0.01 58.5  
Ethnicity  
 Caucasian 3 1.34 0.93–1.93 0.12 67.9 1.76 1.05–2.94 0.03 65.3 1.17 0.72–1.90 0.53 0 1.69 0.98–2.90 0.06 71.5 0.95 0.61–1.49 0.84 0  
 Asian 6 1.72 1.37–2.15 <0.01 60.7 1.59 1.22–2.07 <0.01 58.7 3.15 2.21–4.51 <0.01 0 1.70 1.31–2.23 <0.01 63.6 2.73 1.92–3.89 <0.01 0  
Design  
 PC 6 1.47 1.10–1.96 0.01 70.5 1.62 1.15–2.28 0.01 62.2 1.72 1.18–2.49 <0.01 37.1 1.65 1.17–2.33 <0.01 66.1 1.51 0.89–2.57 0.13 41.4  
 HC 3 1.73 1.28–2.34 <0.01 65.4 1.64 1.19–2.26 <0.01 58.4 3.24 2.09–5.02 <0.01 0 1.74 1.24–2.45 <0.01 66.4 2.80 1.81–4.33 <0.01 0  
Cancer location  
 Oral 4 1.76 1.36–2.27 <0.01 55.2 1.71 1.15–2.54 0.01 71.1 3.13 2.06–4.77 <0.01 0 1.83 1.26–2.66 <0.01 70.1 2.69 1.77–4.09 <0.01 0  
 Nasopharyngeal 4 1.53 1.06–2.20 0.02 76.5 1.75 1.38–2.21 <0.01 5.2 1.81 0.94–3.48 0.07 60.3 1.74 1.28–2.36 <0.01 44.9 1.52 0.79–2.90 0.21 64.2  
−819 T>C   C vs. T TC vs. TT CC vs. TT TC + CC vs.TT CC vs. TT + TC  
Total 6 1.15 1.04–1.21 0.01 20.1 1.24 0.93–1.65 0.14 65.8 1.28 1.03–1.59 0.03 0 1.27 0.99–1.64 0.06 62.0 1.19 0.98–1.45 0.08 0  
HWE-yes 4 1.24 1.07–1.45 0.01 33.3 1.33 0.75–2.37 0.33 78.3 1.53 1.08–2.15 0.02 0 1.41 0.86–2.32 0.18 73.8 1.31 0.99–1.75 0.06 0  
HWE-no 2 1.09 0.96–1.24 0.20 0 1.11 0.93–1.33 0.24 0 1.13 0.85–1.50 0.40 0 1.12 0.95–1.32 0.19 0 1.08 0.82–1.42 0.57 0  
Ethnicity  
 Asian 5 1.16 1.05–1.28 <0.01 29.7 1.27 0.94–1.71 0.12 72.0 1.30 1.04–1.61 0.02 0 1.30 0.99–1.70 0.06 68.7 1.22 0.99–1.51 0.07 0  
Design  
 PC 4 1.24 1.07–1.45 0.01 33.3 1.33 0.75–2.37 0.33 78.3 1.53 1.08–2.15 0.02 0 1.41 0.86–2.32 0.18 73.8 1.31 0.99–1.75 0.06 0  
 HC 2 1.09 0.96–1.24 0.20 0 1.11 0.93–1.33 0.24 0 1.13 0.85–1.50 0.40 0 1.12 0.95–1.32 0.19 0 1.08 0.82–1.42 0.57 0  
Cancer location  
 Oral 3 1.23 0.98–1.54 0.08 63.6 1.44 085–2.44 0.18 85.5 1.6 0.97–1.63 0.09 2.4 1.45 0.90–2.35 0.13 84.3 1.17 0.91–1.50 0.22 0  
 Nasopharyngeal 3 1.15 0.96–1.37 0.13 0 1.10 0.84–1.44 0.49 0 1.33 0.90–1.96 0.15 0 1.16 0.90–1.49 0.25 0 1.22 0.89–1.67 0.22 0  
–592 A>C   C vs. A AC vs. AA CC vs. AA AC+CC vs. AA CC vs. AA+AC  
Total 6 1.11 0.94–1.31 0.22 55.6 1.14 0.84–1.55 0.41 71.2 1.14 0.92–1.41 0.24 22.3 1.17 0.88–1.57 0.29 71.3 1.11 0.92–1.36 0.28 0  
HWE-yes 5 1.16 0.95–1.42 0.14 52.3 1.21 0.79–1.87 0.38 74.9 1.31 0.98–1.76 0.07 8.9 1.26 0.85–1.88 0.26 73.4 1.22 0.94–1.56 0.13 0  
Ethnicity  
 Asian 5 1.13 0.94–1.36 0.22 64.0 1.16 0.84–1.62 0.36 76.7 1.15 0.92–1.43 0.21 35.1 1.20 0.88–1.63 0.25 76.8 1.13 0.92–1.40 0.25 8.5  
Design  
 PC 4 1.24 1.07–1.45 0.01 33.3 1.33 0.75–2.37 0.33 78.3 1.53 1.08–2.15 0.02 0 1.41 0.86–2.32 0.18 73.8 1.31 0.99–1.75 0.06 0  
 HC 2 0.95 0.84–1.08 0.47 0 0.94 0.79–1.12 0.51 0 0.93 0.70–1.24 0.62 0 0.94 0.80–1.11 0.46 0 0.95 0.73–1.26 0.74 0  
Cancer location  
 Oral 3 1.20 0.90–1.60 0.22 77.2 1.09 0.92–1.28 0.32 87.8 1.24 0.82–1.88 0.30 45.5 1.40 0.82–2.40 0.22 87.5 1.10 0.86–1.41 0.46 0  
 Nasopharyngeal 3 1.03 0.87–1.24 0.71 16.3 0.94 0.72–1.23 0.65 0 1.14 0.77–1.69 0.50 27.8 0.99 0.77–1.27 0.91 0 1.14 0.83–1.57 0.42 25.5  

PC: Population control HC: Hospital control.

*Numbers of comparisons.