Fig. 2.

miR-222 is involved in degeneration of human articular chondrocytes. (A) Chondrocytes were isolated from biopsy sample of normal cartilage (normal) and OA cartilage (OA), cultured with or without 5 ng/ml IL-1β. OA. Expression levels of miRs were analyzed. (B) Chondrocytes were isolated from biopsy sample of normal cartilage (normal) and OA cartilage (Non-OA and OA) and expression level of miR-222 (left panel) was analyzed by real-time PCR. Expression level of miR-222 was analyzed using OA chondrocytes isolated from 10 different OA patients (right panel). The mean is plotted and the error bars represent 95% CI (lower/upper limit). *Statistically different from control cells (p < 0.05).