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. 2015 Jan 2;3:90–95. doi: 10.1016/j.bbacli.2014.12.006

Table 2.

Reference values from the literature for thyroid function across trimesters of pregnancy.

Author Year Country fT31
pmol/l
fT32
pmol/l
fT33
pmol/l
fT41
pmol/l
fT42
pmol/l
fT43
pmol/l
TSH1
mIU/l
TSH2
mIU/l
TSH3
mIU/l
Cotzias [43] 2007 U.K. 3–7 3–5.5 2.5–5.5 10–16 9–15.5 8–14.5 0–5.5 0.5–3.5 0.5–4
Soldin [44] 2007 USA TT4: 141.35 nmol/l TT4: 152.95 nmol/l TT4: 142.65 nmol/l 0.91 1.03 1.32
Marwaha [45] 2008 India 1.92–5.86 3.2–5.73 3.3–5.18 12–19.45 9.48–19.58 11.32–17.7 0.6–5.0 0.44–5.78 0.74–5.7
Springer [46] 2009 Czech 9.55–23.0 0.06–3.67
Karakosta [47] 2011 Greece, Crete 2.37–8.02 2.73–8.13 12.23–19.69 11.2–18.66 0.05–2.53 0.18–2.73
Ekinci [48] 2013 Australia 3.9–5.7 3.7–5.2 3.5–5.0 5.9–15.6 4.9–11.3 4.4–11.2 0.03–3.05 0.42–3.36 0.34–2.83
Azizi [49] 2013 Iran 8.5–19.0 (fT4I) 9.7–21.0 (fT4I) 8.7–20.4 (fT4I) 0.2–3.9 0.5–4.1 0.6–4.1
Moreno-Reyes [28] 2013 Belgium 2.8–7.1 10.3–21.9 0.1–2.5 0.3–3.0
This study 2007 Austria 4.93 ± 0.59 4.54 ± 0.48 4.27 ± 0.45 15.23 ± 2.43 13.79 ± 1.99 13.32 ± 2.01 1.46 ± 1.29 1.68 ± 1.23 1.70 ± 2.22

Statistical methods: Cotzias: median; Soldin: mean and median; Marwaha: fT3 + fT4: mean, median & percentile; TSH: log; Springer: mean; Karakosta: mean, median and TSH log; Ekinci: fT3 + fT4: mean; TSH: percentile and log; Azizi: TSH log; Moreno-Reyes: mean, median and log; and this Study: fT3, fT4 means, and log TSH means.