Fig. 5.

Gene expression changes in response to heat stress. Control and HSPB1^∆C-term (patient) fibroblasts were treated by exposure to 45 °C for 30 min and a gene expression microarray was used to measure the alterations in gene expression between treated and untreated cells. Genes that were upregulated by at least 25% in both control and patient cells are shown and categorized into biological pathways. The results show that the early transcriptional response to heat was not altered in the HSPB1^∆C-term fibroblasts. Asterisk indicates p-value < 0.05.