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. 2015 Nov 27;472(Pt 3):367–377. doi: 10.1042/BJ20150660

Figure 1. MI192 inhibits HDAC3 activity and alters tubulin acetylation levels after 24 h of treatment.

Figure 1

(A) The activity of HDAC measured from cell extracts. (B–D) Graphs and representative Western blots showing the effect of treating PC3 cells with a range of MI192 concentrations for 24 h on the levels of acetylated tubulin. (E) Changes in levels of acetylated tubulin after treatment of cells with 10 μM MI192 for 0.5–2 h was analysed by Western blotting. Data are shown as individual points, with means ± S.E.M. superimposed. *P< 0.05 (n=3 experiments).