Table 1. Hodgkin similarity indices calculated for E. coli TS, W.g.b. TS and their mutants modeled using the E. coli TS structure (PDB ID 2G8O) as a template.

	E. coli	E. coli_2K*	E. coli_4K†	W.g.b	W.g.b_mut‡
E. coli	1	0.819	0.052	−0.387	0.454
E. coli_2K*	0.819	1	0.192	−0.151	0.568
E. coli_4K†	0.052	0.192	1	0.731	0.532
W.g.b	−0.387	−0.151	0.731	1	0.325
W.g.b_mut‡	0.454	0.568	0.532	0.325	1

^*E. coli_2K: double mutant, G23K/E86K.

^†E. coli_4K: quadruple mutant, G23K/E82K/E86K/G257K.

^‡W.g.b_mut: W.g.b. TS with four lysines mutated to the corresponding E. coli residues, K23G/K82E/K86E/K257G.