Table 2. Significant proteins identified from substances of MEDLINE for ibuprofen, warfarin, furosemide and sertraline.
| Drug | Extracted enzyme involved in DDIs | Frequency | p value |
|---|---|---|---|
| Ibuprofen | PTGS1 protein, human | 5 | 1.20E-05 |
| Cytochrome P-450 CYP2C9 | 3 | 7.47E-03 | |
| Aryl Hydrocarbon Hydroxylases | 3 | 1.28E-02 | |
| Warfarin | CYP3A4 protein, human | 13 | 0 |
| Cytochrome P-450 CYP3A | 17 | 0 | |
| Prostaglandin-Endoperoxide Synthases | 3 | 2.32E-11 | |
| PTGS2 protein, human | 3 | 2.32E-11 | |
| Cyclooxygenase 2 | 3 | 3.38E-08 | |
| Cytochrome P-450 CYP1A2 | 5 | 1.77E-04 | |
| Cytochrome P-450 CYP2D6 | 5 | 5.10E-04 | |
| CYP3A protein, human | 5 | 5.65E-04 | |
| Steroid 16-alpha-Hydroxylase | 11 | 4.60E-03 | |
| Steroid Hydroxylases | 11 | 7.25E-03 | |
| Aryl Hydrocarbon Hydroxylases | 77 | 8.92E-03 | |
| CYP2C9 protein, human | 67 | 5.81E-02 | |
| Cytochrome P-450 CYP2C9 | 67 | 6.08E-02 | |
| Alanine Transaminase | 3 | 8.32E-02 | |
| Aspartate Aminotransferases | 3 | 8.47E-02 | |
| Furosemide | Thromboxane-A Synthase | 3 | 0 |
| Glutathione Transferase | 3 | 1.78E-15 | |
| Sertraline | CYP3A protein, human | 8 | 0 |
| Mixed Function Oxygenases | 14 | 0 | |
| Cytochrome P-450 Enzyme System | 18 | 0 | |
| Cytochrome P-450 CYP3A | 8 | 0 | |
| Steroid 16-alpha-Hydroxylase | 5 | 0 | |
| Steroid Hydroxylases | 5 | 0 | |
| Aryl Hydrocarbon Hydroxylases | 8 | 0 | |
| Cytochrome P-450 CYP2D6 | 9 | 0 | |
| Cytochrome P-450 CYP2C9 | 4 | 1.76E-13 | |
| CYP2C9 protein, human | 4 | 1.76E-13 | |
| Cytochrome P-450 CYP1A2 | 3 | 2.82E-12 | |
| Cytochrome P-450 CYP2C19 | 3 | 4.10E-06 | |
| CYP2C19 protein, human | 3 | 4.10E-06 | |
| Receptor, Serotonin, 5-HT1A | 3 | 6.95E-03 |