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. 2015 Nov 27;5:17151. doi: 10.1038/srep17151

Table 4. Association between the studied TGFB3/TNF genotypes and sperm parameters in infertile (n = 344) and fertile (n = 124) men.

Sperm parameters Unit Group TNF rs1800629 genotype p value
GG GA AA p1 p2 p3
Concentration ×106/mL infertile 39.7 ± 37.2 40.6 ± 38.9 33.7 ± 23.8 0.944 0.738 0.981
  fertile 82.1 ± 74.3 94.5 ± 67.5 ND – 0.198 –
Morphologically normal spermatozoa % infertile 4.5 ± 4.8 4.5 ± 4.9 4.5 ± 4.8 0.981 0.851 0.929
  fertile 10.2 ± 7.3 10.7 ± 6.4 ND – 0.513 –
Progressive motility % infertile 39.7 ± 21.9 40.1 ± 21.6 31.0 ± 16.7 0.611 0.959 0.338
  fertile 49.2 ± 16.8 40.1 ± 16.3 ND – 0.035 –
Non-progressive motility % infertile 13.8 ± 10.2 13.0 ± 11.2 11.6 ± 6.4 0.585 0.303 0.776
  fertile 18.1 ± 9.2 22.1 ± 10.8 ND – 0.084 –
Total motility % infertile 53.5 ± 19.9 52.2 ± 19.7 42.6 ± 12.0 0.357 0.516 0.166
  fertile 67.5 ± 14.6 62.1 ± 14.9 ND – 0.221 –
Immotile spermatozoa % infertile 45.7 ± 19.9 45.4 ± 19.7 57.4 ± 12.0 0.335 0.796 0.140
  fertile 32.5 ± 14.6 37.8 ± 14.9 ND – 0.230 –
Sperm parameters unit   TGFB3 rs2268626 genotype p value
TT CT CC p1 p2 p3
Concentration ×106/mL infertile 40.8 ± 40.3 39.1 ± 32.0 27.4 ± 25.4 0.440 0.781 0.257
  fertile 87.9 ± 76.3 80.5 ± 69.7 65.4 ± 20.4 0.876 0.618 0.974
Morphologically normal spermatozoa % infertile 4.5 ± 4.9 4.6 ± 4.6 3.7 ± 4.9 0.487 0.654 0.238
  fertile 10.9 ± 7.3 9.5 ± 6.9 6.4 ± 2.1 0.326 0.226 0.239
Progressive motility % infertile 39.3 ± 21.8 41.5 ± 21.8 30.4 ± 19.0 0.208 0.673 0.120
  fertile 50.7 ± 17.8 40.1 ± 16.7 41.0 ± 10.6 0.024 0.006 0.469
Non-progressive motility % infertile 14.1 ± 10.9 13.0 ± 9.6 9.2 ± 5.5 0.326 0.272 0.207
  fertile 18.6 ± 10.3 18.3 ± 7.5 30.2 ± 8.2 0.034 0.289 0.010
Total motility % infertile 53.1 ± 19.5 54.4 ± 20.6 39.6 ± 18.8 0.414 0.924 0.016
  fertile 69.3 ± 14.6 58.9 ± 13.3 70.8 ± 9.6 0.002 0.002 0.465
Immotile spermatozoa % infertile 46.5 ± 19.4 43.7 ± 20.1 52.1 ± 21.6 0.156 0.471 0.124
  fertile 30.7 ± 14.6 41.1 ± 13.3 28.8 ± 9.8 0.002 0.002 0.427
Sperm parameters unit   TGFB3 rs3917158 genotype p value
CC CT TT p1 p2 p3
Concentration ×106/mL infertile 41.4 ± 39.9 36.9 ± 32.1 32.1 ± 27.9 0.886 0.678 0.728
  fertile 80.1 ± 77.5 78.6 ± 63.9 65.5 ± 20.4 0.950 0.758 0.974
Morphologically normal spermatozoa % infertile 4.6 ± 4.9 4.3 ± 4.4 4.8 ± 5.8 0.642 0.357 0.716
  fertile 10.9 ± 7.6 9.1 ± 5.9 6.4 ± 2.1 0.326 0.214 0.238
Progressive motility % infertile 39.6 ± 21.6 40.2 ± 22.4 35.1 ± 19.7 0.785 0.961 0.507
  fertile 49.0 ± 18.6 42.8 ± 11.6 41.0 ± 10.6 0.308 0.131 0.469
Non-progressive motility % infertile 14.0 ± 10.7 13.0 ± 9.8 9.0 ± 5.3 0.326 0.253 0.231
  fertile 18.5 ± 10.1 18.4 ± 7.5 30.2 ± 8.2 0.034 0.245 0.010
Total motility % infertile 53.3 ± 19.4 53.2 ± 21.4 44.1 ± 16.9 0.331 0.827 0.139
  fertile 67.6 ± 15.9 61.8 ± 10.8 70.8 ± 9.6 0.085 0.083 0.466
Immotile spermatozoa % infertile 46.3 ± 19.3 43.9 ± 20.8 55.9 ± 16.9 0.196 0.645 0.110
  fertile 32.4 ± 15.9 38.2 ± 10.8 28.8 ± 9.8 0.085 0.085 0.427
Sperm parameters unit   TGFB3 rs2284792 genotype p value
AA AG GG p1 p2 p3
Concentration ×106/mL infertile 40.6 ± 38.2 40.1 ± 37.5 27.8 ± 25.8 0.425 0.986 0.204
  fertile 93.0 ± 81.8 74.3 ± 58.5 60.7 ± 21.8 0.622 0.335 0.705
Morphologically normal spermatozoa % infertile 4.7 ± 5.1 4.2 ± 4.3 4.2 ± 5.0 0.467 0.251 0.475
  fertile 10.8 ± 6.8 10.0 ± 7.9 6.3 ± 1.9 0.270 0.194 0.203
Progressive motility % infertile 39.9 ± 22.3 40.3 ± 21.0 32.3 ± 21.8 0.311 0.871 0.131
  fertile 49.7 ± 16.5 44.5 ± 17.6 36.2 ± 15.1 0.114 0.060 0.171
Non-progressive motility % infertile 13.8 ± 10.9 13.5 ± 10.1 10.9 ± 6.5 0.797 0.748 0.506
  fertile 19.0 ± 9.7 17.4 ± 9.2 30.0 ± 7.4 0.012 0.989 0.004
Total motility % infertile 53.3 ± 20.1 53.8 ± 19.5 43.2 ± 20.4 0.094 0.760 0.031
  fertile 68.7 ± 14.0 62.3 ± 15.5 65.8 ± 14.9 0.086 0.034 0.985
Immotile spermatozoa % infertile 46.2 ± 20.1 44.7 ± 19.1 50.6 ± 21.5 0.304 0.868 0.149
  fertile 31.3 ± 13.9 37.7 ± 15.5 33.8 ± 15.1 0.084 0.035 0.938
Sperm parameters unit   TGFB3 rs2268625 genotype p value
TT TC CC p1 p2 p3
Concentration ×106/mL infertile 41.3 ± 39.8 37.4 ± 32.2 29.1 ± 27.6 0.746 0.731 0.453
  fertile 86.3 ± 75.4 83.9 ± 71.8 65.5 ± 20.4 0.997 0.946 0.974
Morphologically normal spermatozoa % infertile 4.6 ± 4.9 4.4 ± 4.4 4.3 ± 5.6 0.656 0.456 0.488
  fertile 11.0 ± 7.6 9.1 ± 5.8 6.4 ± 2.1 0.349 0.247 0.238
Progressive motility % infertile 39.5 ± 21.7 40.5 ± 22.5 34.5 ± 18.5 0.698 0.896 0.435
  fertile 49.3 ± 18.7 42.4 ± 11.4 41.0 ± 10.6 0.183 0.067 0.469
Non-progressive motility % infertile 14.1 ± 10.7 12.8 ± 9.9 10.2 ± 6.2 0.358 0.178 0.426
  fertile 18.3 ± 10.2 18.9 ± 7.6 30.2 ± 8.2 0.027 0.134 0.010
Total motility % infertile 53.3 ± 19.4 53.2 ± 21.6 44.7 ± 16.0 0.322 0.836 0.135
  fertile 67.7 ± 16.1 61.8 ± 10.5 70.8 ± 9.6 0.070 0.065 0.465
Immotile spermatozoa % infertile 46.3 ± 19.3 43.8 ± 20.9 55.2 ± 15.9 0.180 0.632 0.105
  fertile 32.3 ± 16.1 38.2 ± 10.5 28.8 ± 9.8 0.066 0.068 0.427
Sperm parameters unit   TGFB3 rs3917187 genotype p value
CC CT TT p1 p2 p3
Concentration ×106/mL infertile 40.0 ± 36.6 41.1 ± 40.1 28.0 ± 24.3 0.549 0.927 0.282
  fertile 88.1 ± 78.8 82.4 ± 66.1 60.7 ± 21.8 0.928 0.952 0.704
Morphologically normal spermatozoa % infertile 4.6 ± 4.7 4.4 ± 5.0 3.9 ± 4.7 0.522 0.293 0.503
  fertile 10.9 ± 7.2 9.9 ± 7.3 6.3 ± 1.9 0.317 0.255 0.203
Progressive motility % infertile 39.8 ± 22.0 40.0 ± 21.6 36.3 ± 20.7 0.749 0.876 0.449
  fertile 48.5 ± 17.7 46.5 ± 15.8 36.2 ± 15.1 0.274 0.232 0.171
Non-progressive motility % infertile 13.6 ± 10.6 13.6 ± 10.6 12.7 ± 5.8 0.853 0.802 0.676
  fertile 18.3 ± 9.3 18.7 ± 9.9 30.0 ± 7.4 0.017 0.330 0.004
Total motility % infertile 53.0 ± 20.2 53.5 ± 19.7 49.0 ± 19.0 0.464 0.908 0.222
  fertile 66.8 ± 15.7 65.5 ± 13.2 65.8 ± 14.9 0.727 0.450 0.986
Immotile spermatozoa % infertile 44.4 ± 20.1 44.0 ± 19.1 51.0 ± 19.0 0.276 0.676 0.167
  fertile 33.2 ± 15.7 34.5 ± 13.2 33.8 ± 15.1 0.721 0.457 0.939

Mean values and standard deviation are presented; ND - genotypes were not detected in subjects with sperm parameters available; p1 – overall comparison – Kruskal-Wallis test; p2 – dominant model (minor homozygotes and heterozygotes vs. major homozygotes) – U-test; p3 –recessive model (minor homozygotes vs. other genotypes) -U-test.