Table 3.
Distributions of genotypes of and their associations with risk of CWP.
| Variables | CWP Cases | Controls | p a | OR (95% CI) | OR (95% CI) b | ||
|---|---|---|---|---|---|---|---|
| N | % | N | % | ||||
| rs1799750 | n = 690 | n = 683 | |||||
| 2G/2G | 276 | 40.0 | 309 | 45.2 | 0.082 | 1.00 | 1.00 |
| 2G/1G | 325 | 47.1 | 305 | 44.7 | 1.19 (0.95–1.49) | 1.19 (0.95–1.49) | |
| 1G/1G | 89 | 12.9 | 69 | 10.1 | 1.44 (1.01–2.06) | 1.45 (1.02–2.07) | |
| 2Gallele | 877 | 63.6 | 923 | 67.6 | 1.00 | ||
| 1Gallele | 503 | 36.4 | 443 | 32.4 | 0.027 | 1.20 (1.02–1.40) | 1.20 (1.02–1.40) |
| ADD | 0.026 | 1.20 (1.02–1.41) | |||||
| DOM | 0.050 | 1.24 (1.00–1.54) | 1.24 (1.00–1.54) | ||||
| REC | 0.104 | 1.32 (0.94–1.84) | 1.32 (0.94–1.85) | ||||
| rs2285053 | n = 690 | n = 682 | |||||
| CC | 409 | 59.3 | 395 | 57.9 | 0.684 | 1.00 | 1.00 |
| CT | 252 | 36.5 | 252 | 37.0 | 0.97 (0.77–1.21) | 0.98 (0.79–1.23) | |
| TT | 29 | 4.2 | 35 | 5.1 | 0.80 (0.48–1.33) | 0.79 (0.47–1.32) | |
| C allele | 1070 | 77.5 | 1042 | 76.4 | 1.00 | ||
| T allele | 310 | 22.5 | 322 | 23.6 | 0.477 | 0.94 (0.78–1.12) | 0.94 (0.79–1.13) |
| ADD | 0.468 | 0.94 (0.78–1.12) | |||||
| DOM | 0.610 | 0.94 (0.76–1.17) | 0.96 (0.77–1.19) | ||||
| REC | 0.414 | 0.81 (0.49–1.34) | 0.80 (0.48–1.32) | ||||
| rs522616 | n = 690 | n = 675 | |||||
| AA | 301 | 43.6 | 276 | 40.9 | 0.130 | 1.00 | 1.00 |
| AG | 309 | 44.8 | 296 | 43.8 | 0.96 (0.76–1.20) | 0.96 (0.76–1.20) | |
| GG | 80 | 11.6 | 103 | 15.3 | 0.71 (0.51–0.99) | 0.70 (0.50–0.98) | |
| A allele | 911 | 66.0 | 848 | 62.8 | 1.00 | ||
| G allele | 469 | 34.0 | 502 | 37.2 | 0.081 | 0.87 (0.74–1.02) | 0.86 (0.74–1.01) |
| ADD | 0.086 | 0.87 (0.75–1.02) | |||||
| DOM | 0.307 | 0.89 (0.72–1.11) | 0.89 (0.72–1.10) | ||||
| REC | 0.047 | 0.73 (0.53–0.99) | 0.72 (0.52–0.99) | ||||
a two-sided χ2 test; b adjusted for age, exposure years, working status, and pack-years of smoking in logistic regression model. ADD: additive model; DOM: dominant model; REC: recessive model.