Table 4.
Stratification analyses between the genotypes of MMP3 rs522616 and CWP risk.
| Variables | Cases/Controls | Genotypes (Cases/Controls) | p a | OR (95% CI) a | |||
|---|---|---|---|---|---|---|---|
| AA/AG | GG | ||||||
| n | % | n | % | ||||
| Total age | 690/675 | 610/572 | 88.4/84.7 | 80/103 | 11.6/15.3 | 0.041 | 0.72 (0.52–0.99) |
| <68 | 275/397 | 246/335 | 89.4/84.4 | 29/62 | 10.6/15.6 | 0.199 | 0.72 (0.43–1.19) |
| ≥68 | 415/278 | 364/237 | 87.7/85.2 | 51/41 | 12.3/14.8 | 0.379 | 0.82 (0.52–1.28) |
| Exposure years | |||||||
| <27 | 268/261 | 236/216 | 88.1/82.8 | 32/45 | 11.9/17.2 | 0.060 | 0.62 (0.38–1.02) |
| ≥27 | 422/414 | 374/356 | 88.6/86.0 | 48/58 | 11.4/14.0 | 0.268 | 0.79 (0.52–1.20) |
| Smoking status | |||||||
| Never | 339/351 | 302/295 | 89.1/84.0 | 37/56 | 10.9/16.0 | 0.049 | 0.64 (0.41–1.00) |
| Ever | 351/324 | 308/277 | 87.8/85.5 | 43/47 | 12.2/14.5 | 0.344 | 0.81(0.52–1.26) |
| Stage | |||||||
| I | 413/675 | 368/572 | 89.1/84.7 | 45/103 | 10.9/15.3 | 0.032 | 0.66 (0.45–0.96) |
| II | 216/675 | 193/572 | 89.4/84.7 | 23/103 | 10.6/15.3 | 0.213 | 0.73 (0.44–1.20) |
| III | 61/675 | 49/572 | 80.3/84.7 | 12/103 | 19.7/15.3 | 0.188 | 1.59 (0.80–3.18) |
a adjusted for age, exposure years, job type, and pack-years of smoking in logistic regression model.