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. 2015 Nov 27;5:17220. doi: 10.1038/srep17220

Figure 1. Schematic overview of CLP, NLP and NLP-biotin-RPE liposomes.

Figure 1

We synthesized a new DPPC-based liposome (NLP) containing gadolinium-DOTA lipid and compared its characteristics to more conventional DSPC-based liposome with gadolinium-DTPA-BSA (CLP). In order to make NLP multifunctional, a biotin and rhodamine containing lipid was added to the formulation so the liposome can be traced both with magnetic resonance and fluorescence imaging and can be targeted using the strong biotin-streptavidin interaction (NLP-biotin-RPE).