Figure 3. Involvement of PGIS and mPGES-1 in thioglycollate-induced peritonitis.
Number and morphology of exudate leukocytes (A,B) and prostanoid levels in peritoneal fluids (C) from thioglycollate-treated PGIS and/or mPGES-1 KO mice. (A) Peritoneal exudate cells and fluids were collected from mice on day 0, 2 or 4 after the injection of thioglycollate. The peritoneal cells were washed and then counted. (B) Representative Giemsa staining of cytocentrifuge preparations of the exudate leukocytes on day 4. (C) The peritoneal fluids were subjected to a lipidomics analysis by LC-ESI-MS. Results are mean ± SEM (n = 3–6). *P < 0.05 and **P < 0.01 vs. control.