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. 2015 Jul 23;4:59–68. doi: 10.1016/j.bbacli.2015.07.001

Fig. 7.

Fig. 7

Model of AKT and GSK3α/β-mediated pathways in AML cells. Extracellular survival signals activate AKT which suppresses GSK3α/β. When AKT is suppressed, FOXO3A and PKCδ are inhibited independent of GSK3α/β. GSK3α/β when active will suppress MYC, MCL-1, and β-catenin.