Figure 1.
Macroscopic and histological examinations of the repaired tissue in partial-thickness defect at eight week post-operation. The red circle regions are the defects of articular cartilage. Sections were stained with hematoxylin and eosin (HE), Safranin O, or immunohistochemical collagen type II (Anti-Col2). Sham, sham-operated group; Control, group only treated with collagen membrane without BMP3 as negative control; BMP3, group treated with the collagen membrane and BMP3 at 100 ng/cm2, respectively. D and C stand for defect area and chondrocyte-like cells, respectively. Scale bar is 100 μm.