Table 4.
The effects of some antioxidants/plants on drugs-induced liver damage.
| Models (Prevent/Treatment) | Materials | Effects | Dose (Dose-Effect) | References |
|---|---|---|---|---|
| Paracetamol-induced liver toxicity in mice (Prevent) | Gallic acid | Antioxidation, hepatoprotection | 100 mg/kg | [129] |
| Paracetamol-induced liver toxicity in mice (Prevent) | Sauchinone | Antioxidation, hepatoprotection | 30 mg/kg | [130] |
| Paracetamol-induced liver toxicity in mice (Prevent) | Genistein | Antioxidation, hepatoprotection | 50, 100 and 200 mg/kg (Dose-effect) | [131] |
| Paracetamol-induced liver toxicity in mice (Prevent) | Phyllanthus niruri | Antioxidation, hepatoprotection | 100 mg/kg | [132] |
| Paracetamol-induced liver toxicity in mice (Prevent) | Polyalthia longifolia leaves | Antioxidation, hepatoprotection | 200 mg/kg | [133] |
| Paracetamol-induced liver damage in rats (Prevent) | Boerhaavia diffusa leaves | Antioxidation, hepatoprotection | 100, 200, 300 and 400 mg/kg/day (No dose-effect) | [134] |
| Paracetamol-induced liver damage in rats (Prevent) | Saponarin from Gypsophila trichotoma | Antioxidation, hepatoprotection | 80 mg/kg/week | [135] |
| Lipopolysaccharide-induced liver injury in rats (Prevent) | Carnosic acid | Antioxidation, hepatoprotection | 15, 30 and 60 mg/kg (Dose-effect) | [136] |
| d-Galactosamine-induced liver injury in rats (Prevent) | Combination of selenium, ascorbic acid, β-carotene, and α-tocopherol | Antioxidation, hepatoprotection | [137] | |
| d-Galactosamine-induced liver injury in rats (Prevent) | Leucasaspera | Antioxidation, hepatoprotection | 200 and 400 mg/kg (No dose-effect) | [138] |
| d-Galactosamine-induced liver injury in rats (Prevent) | Swertiamarin from Enicostemma axillare | Antioxidation, hepatoprotection | 100 and 200 mg/kg (No dose-effect) | [139] |
| Lipopolysaccharide/d-galactosamineinduced liver injury in rats (Prevent) | Curcumin | Antioxidation, hepatoprotection | 100 mg/kg | [140] |
| Lipopolysaccharide/d-galactosamineinduced liver injury in rats (Prevent) | betulinic acid | Antioxidation, hepatoprotection | 20 and 50 mg/kg (No dose-effect) | [141] |
| Lipopolysaccharide/d-galactosamine induced hepatitis in rats (Prevent) | Tridaxprocumbens | Antioxidation | 300 mg/kg | [142] |
| Doxorubicin-induced liver injury in rats | N-acetylcysteine | Antioxidation, hepatoprotection | 10 mg/kg | [143] |
| Cisplatin-induced liver injury in rats (Prevent) | Tomato juice | Antioxidation, hepatoprotection | [144] | |
| Tert-butyl hydroperoxide-induced liver injury in rats (Prevent) | Propolis | Antioxidation, hepatoprotection | 50 and 100 mg/kg (No dose-effect) | [145] |
| Tamoxifen-induced liver injury in mice (Prevent) | Catechin | Antioxidation | 40 mg/kg | [146] |
| Hepatic steatosis stimulated with tunicamycin (Treatment) | Melatonin | ↓ ER stress, expression of miR-23a | [147] | |
| Ethionine-induced liver injury in mice (Prevent) | Melatonin | Antioxidation, hepatoprotection | 3 mg/kg | [148] |