Table 6.
Effects of some antioxidants/plants on other related liver disease.
| Stress (Prevent/Treatment) | Antioxidant/Plants | Effects | Dose (Dose–Effect) | Bioactive Compounds | References |
|---|---|---|---|---|---|
| Human liver cancer cell line | Morinda pubescens leaves | Antioxidation, cytotoxicity | 25, 50, 100 and 250 μg/mL b.w. (Dose–effect) | Hyoscyamine | [220] |
| Liver cancer of rats (Prevent) | Chlorella vulgaris | Antioxidation, antitumour | 50, 150 and 300 mg/mL b.w. (Dose–effect) | [221] | |
| Hepatocellular carcinoma | Caesalpinia bonducella leaves | ↑ SOD, GSH, CAT; ↓ MDA, AST, ALT, ALP; anticancer | Flavonoids, triterpenoids | [222] | |
| Liver cancer of mice (Prevent) | Pleurotus pulmonarius (edible mushroom) | Antioxidation, anti-tumor | [158] | ||
| Rat with secondary biliary cirrhosis (Prevent) | Silybin | Antioxidation | 0.4 g/kg b.w. | [223] | |
| Cholestatic rats with bile duct ligation (Treatment) | Green tea catechin | Antioxidation, reducing hepatic fibrosis | 50 mg/kg b.w. | [161] | |
| Bile duct-ligated cholestatic rats (Treatment) | Epigallocatechin-3-gallate | Anti-fibrotic effects, ↓ phosphorylation of Smad2/3 and Akt | 5 mg/kg b.w. | [224] | |
| Bile duct-ligated cholestatic rats (Treatment) | Holothuria arenicola | ↑ SOD, GSH, GST, CAT; ↓ MDA, AST, ALT, ALP | 200 mg/kg b.w. | Phenolic compounds, chlorogenic acid, pyrogallol, rutin, coumaric acid | [225] |
| Bile-duct ligated Rats (Treatment) | Garlic | ↑ GSH; ↓ LDH, TB, MDA, MPO; ↓ TNF-α, TGF-β, MMP-13 | [226] | ||
| Bile-duct ligated Rats (Treatment) | thymoquinone | ↑ SOD, GSH-Px; ↓ MDA | 50 mg/kg b.w. | [227] | |
| Bile-duct ligated Rats (Treatment) | N-acetylcysteine | ↑ GSH, CAT; ↓ MDA, ALT | 300 mg/kg b.w. | [228] | |
| Bile-duct ligated Rats (Prevent) | Phaseolus trilobus | ↑ SOD; ↓ AST, ALT, ALP, LDH, TB, TBARS; | 125, 250 and 500 mg/kg b.w. (Dose–effect) | [229] | |
| Bile-duct ligated Rats (Treatment) | Melatonin | ↓ TBARS, MPO | 10 and 100 mg/kg b.w. (Dose–effect) | [230] | |
| Ischemia/reperfusion in obese rats with fatty liver | Melatonin | ↑ Antioxidant enzymes; ↓ AST, ALT, MAD, NOx metabolites | 10 mg/kg b.w. | [231] | |
| Bile-duct ligated Rats (Treatment) | Allopurinol | ↓ ROS, brain edema | 100 mg/kg b.w. | [232] | |
| Restraint stress-induced liver injury in mice (Prevent) | Astragali radix and Salviae radix | Antioxidation, hepatoprotection | 50, 100 and 200 mg/kg b.w. (No dose–effect) | Myelophil | [233] |