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. 2015 Nov 5;16(11):26555–26581. doi: 10.3390/ijms161125971

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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General scheme of S23906-1 cellular mechanism of action and repair. ROS, reactive oxygen species; CytC, cytochrome C; Detox, detoxification process; DSB, double strand break; DNApol, DNA polymerase; TC-NER, transcription-coupled nucleotide excision repair; GG-NER, global genome nucleotide excision repair; MMR, mismatch repair; HR, homologous repair. Solid and dash circles represent the cellular membrane and the nucleus, respectively. M, G1, S and G2 correspond to the different phases of the cell cycle. Open arrows and stop arrows correspond to activation and inhibition, respectively.