Figure 2.

Increased efficacy of PDT vaccine when combined with cyclophosphamide treatment. Mice with SCCVII tumors were treated with PDT vaccine as described for Figure 1. Single injection of cyclophosphamide (25 mg/kg i.p.) was given four days post vaccination. The results are presented as percentages of mice with tumors smaller than 300 mm³ in function of time after vaccination. Each treatment group consisted of six mice. Statistically significant (p < 0.05) were the differences between the control untreated group response and all three treatment group responses, between vaccine alone response and vaccine plus cyclophosphamide response, and between vaccine plus cyclophosphamide and cyclophosphamide alone responses.