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. 2015 Nov 13;16(11):27133–27144. doi: 10.3390/ijms161126012

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).

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Early (in blue) and current (in green) matrix-assisted laser desorption/ionization (MALDI)-based serum peptide and protein profiles obtained after reversed-phase (RP) C18-magnetic bead cleanup. The MALDI-time-of-flight (TOF) profile in the upper panel is composed of a low-resolution linear mode spectrum (up to m/z-value 11,000) and a high-resolution reflectron mode spectrum (up to m/z-value 4600); in the lower panel a MALDI- Fourier transform ion cyclotron resonance (FTICR) profile of the same sample is shown.