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. 2015 Nov 26;10:67. doi: 10.1186/s13062-015-0096-z

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© Altstein. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The mechanism of the progene formation. 1—dinucleotide; 2—aminoacyl nucleotide; 3—amino acid; 4–3′ “tail”(p ~ pX ~ Aa, see text); 5—complementary H-bonds between “triplets”; 6—phosphodiesther bond; 7—stacking between nucleotides; 8—progene. a Formation of a unstable “triplet” between a dinucleotide (DN) and a aminoacyl nucleotide (AAN) due to stacking and specific interaction between the amino acid (Aa) and DN. b Formation of complementary interaction between two unstable “triplets”; the condition for formation of the template-directed phosphodiesther bond (PDEB) takes place between 2nd and 3d (amino acyl) nucleotides. c The progene; arises on B-stage after PDEB formation between the DN and the AAN; contains the nucleotide triplet, Aa specific for the DN and two macroerges (NpNpNp ~ pX ~ Aa)