. Author manuscript; available in PMC: 2016 Dec 1.

Published in final edited form as: Clin Chest Med. 2015 Dec;36(4):669–683. doi: 10.1016/j.ccm.2015.08.009

Table 3.

Examples of steroid-sparing systemic immunosuppressive agents that may be used for the treatment of ocular sarcoidosis

Medication	Dose	Expected onset of action
Antimetabolites
- Methotrexate	7.5-25 mg/week PO, SQ or IM	2-12 weeks
- Mycophenolate mofetil	500-1500 mg PO twice daily	2-12 weeks
- Azathioprine	1-4 mg/kg/day PO daily	4-12 weeks
Calcineurin inhibitors
- Cyclosporine	2.5-10 mg/kg/day PO twice daily	2-6 weeks
- Tacrolimus	0.15-0.30 mg/kg/day PO	2-6 weeks

IM = intramuscularly; PO = orally; SQ = subcutaneously

Adapted from Jabs DA, Rosenbaum JT, Foster CS, Holland GN, Jaffe GJ, Louie JS, Nussenblatt RB, Stiehm ER, Tessler H, Van Gelder RN, Whitcup SM, Yocum D. Guidelines for the use of immunosuppressive drugs in patients with ocular inflammatory disorders: recommendations of an expert panel. Am J Ophthalmol. 2000;130(4):492-513; with permission.