Table 4.
Summary of Clusters Showing Effects in Whole-Brain Regressions
| Cluster | X | Y | Z | Voxels | BA | Mean r-to-z | t | Effect | Concurrent | Follow-Up |
|---|---|---|---|---|---|---|---|---|---|---|
| Main Effects of GPS | ↑ GPS | |||||||||
| Left Putamen | −16 | 9 | 3 | 41 | - | 0.043 | 3.338** | ↓/weaker connectivity | - | - |
| Left Post-Central Gyrus | −50 | −15 | 48 | 47 | 3 | −0.011 | −0.891 | ↑/weaker connectivity | Ext, Reg | Reg |
| Main Effect of Life Events | ↑ LE | |||||||||
| Left Anterior Cingulate | −20 | 42 | 3 | 23 | 32 | −0.101 | −7.346*** | ↑/weaker connectivity | Anx, Ext | Anx |
| GPS x LE Interactions | ↑ LE with high GPS, ↓LE with low GPS | |||||||||
| Right Parahippocampal Gyrus | 28 | −48 | 0 | 129 | 19 | 0.053 | 4.756*** | ↓/weaker connectivity | Reg | - |
| Left Caudate Tail | −34 | −33 | 0 | 22 | - | 0.093 | 7.683*** | ↓/weaker connectivity | - | - |
| Left Middle Frontal Gyrus | −40 | 27 | 39 | 66 | 8 | −0.139 | −11.563*** | ↑/weaker connectivity | - | - |
| Left Inferior Frontal Gyrus | −50 | 6 | 33 | 22 | 9 | −0.045 | −3.048** | ↑/weaker connectivity | Dep, Anx | - |
Clusters showing significant effects of genetic profile scores (GPS), life events (LE), or their interaction in the whole brain regressions are listed here. Their peak Talairach co-ordinates (X,Y,Z) for each cluster, voxel extent, and Brodmann area (BA) are presented. The mean r-to-z connectivity values for each cluster with the left amygdala and associated one sample t-statistic testing a null hypothesis of mean zero connectivity are also presented. The direction of effects are summarized along with relationships with concurrent and follow-up scores (Dep=depressive, Anx=anxiety, Ext=externalizing disorder symptoms, Reg=ERC emotion regulation scores) ↑/↓ = higher or lower values of a variable.
p<0.05,
p<0.01,
p<0.001