TABLE 1.
A Selection of Lantibiotics and their Potential Therapeutic Applications.
| Lantibiotic | Commercially relevant targets | In vivo tests | Potential applications | Reference |
|---|---|---|---|---|
| Nisin | Gram positive bacteria | ✓ | Treatment of staphylococcal (including MRSA) and enterococcal infections. Treatment of bacterial mastitis. Oral hygiene, deodorants. Anti-cancer | Mota-Meira et al., 2000; Brumfitt et al. (2002); Cotter et al. (2005); Piper et al., 2009b; Joo et al. (2012); Kamarajan et al. (2015) |
| Mersacidin | MRSA VRE, C. difficile | ✓ | Treatment of staphylococcal (including MRSA) and enterococcal infections. Treatment of CDAD | Niu and Neu (1991); Hoffmann et al. (2002); Appleyard et al. (2009) |
| Actagardine | MRSA, VRE, C. difficile | ✓ | Treatment of staphylococcal (including MRSA) and enterococcal infections. Treatment of CDAD | Hoffmann et al. (2002) |
| Deoxyactagardine/NVB302 | C. difficile | ✓ | Treatment of C. difficile infections | Dawson and Scott (2012) |
| Gallidermin/Epidermin | Propionibacteria, Staphylococci, Streptococci | ✓ | Skin disorders including acne, eczema, folliculitis and impetigo | Bonelli et al. (2006) |
| Pinensins | Yeast/fungi | ✓ | Antifungal/yeast | Mohr et al. (2015) |
| Planosporicin | MRSA, VRE, Streptococci | ✓ | Treatment of staphylococcal (including MRSA) and enterococcal infections including VRE | Castiglione et al. (2007) |
| Microbisporicin | MRSA, VISA, VRE, C. difficile | ✓ | Treatment of staphylococcal (including MRSA and VISA) and enterococcal infections including VRE. Acne | Castiglione et al. (2008) |
| Mutacin B-Ny266 | Multi-drug resistant bacteria | ✓ | Treatment of multi-drug resistant bacteria including MRSA and VRE | Mota-Meira et al., 2000 |
| Lacticin 3147 | Gram positive bacteria | ✓ | Treatment of bacterial mastitis. staphylococcal and enterococcal infections including VRE. Acne | Galvin et al. (1999); Lawton et al. (2007); Piper et al. (2009b) |
| Salivaricin B | Streptococci including S. pyogenes and S. sobrinus | ✓ | Treatment of streptococcal infections with emphasis on the causative agents of sore throats (caused mainly by S. pyogenes) and dental caries (caused in part by S. sobrinus). | Tagg (2004); Wescombe et al. (2009) |
| Duramycin | Increase chloride transport and fluid secretions | ✓ | Treatment of Cystic Fibrosis, ocular diseases and disorders | Grasemann et al. (2007); Oliynyk et al. (2010) |