Table 4.

Association between HDRS scores and the genotypes of ABCB1

	C3435T			p value	G2677T			p value	C1236T			p value
	C/C	C/T	T/T		G/G	G/T	T/T		C/C	C/T	T/T
Age (yr)	39.9±15.2	42.2±11.1	40.8±10.6	0.834	39.2±12.8	44.7±10.1	41.0±12.0	0.420	39.3±16.0	41.3±11.6	14.8±10.8	0.860
Initial HDRS score	25.2±6.6	25.7±5.9	25.9±5.5	0.946	24.3±6.2	26.3±5.7	26.9±5.4	0.331	22.7±5.7	26.0±6.3	26.6±5.4	0.206
HDRS score after treatment	6.0±5.7	9.1±8.3	6.1±5.0	0.303	5.2±5.6	6.5±5.7	10.6±8.5	0.050	6.6±7.0	6.7±6.8	8.3±7.5	0.715
HDRS change (%)				0.908*				0.002*,‡				0.554*
Week 2	−43.6±30.5	−36.5±30.7	−39.4±33.7		−26.3±34.3	−44.3±24.9	−53.8±29.5		−36.1±30.2	−48.7±31.0	−36.1±31.4
Week 4	−43.4±30.5	−54.7±28.7	−61.5±24.3		−34.3±28.5	−60.9±39.5	−68.3±23.1		−48.2±53.2	−60.2±26.8	−50.7±31.7
Week 6	−77.7±23.6	−62.1±40.1	−76.6±17.9		−56.5±42.1	−74.6±22.9	−79.9±20.2		−73.9±23.9	−70.7±38.9	−68.8±28.8
Cortisol (ng/ml)				0.363†				0.151†				0.531†
Initial	11.1±4.6	14.9±6.1	16.2±7.3		13.2±6.3	16.4±5.9	14.1±6.6		10.9±6.0	15.7±6.2	14.6±6.3
Week 6	13.2±5.7	13.5±5.7	13.0±6.7		11.4±5.8	14.8±6.2	14.4±5.4		14.3±6.4	12.3±6.1	13.7±5.8

Values are presented as mean±standard deviation.

HDRS, 21-item Hamilton Depression Rating Scale.

^*Repeated measurements analysis was used to determine changes in HDRS scores over time after adjustment by initial HDRS score, age, and gender.

^†Repeated measurements analysis was used to determine cortisol level over time after adjustment by initial HDRS score, age, and gender.

^‡Significant after Bonferroni correction (p<0.017 needed).