Table 5.
Formulation of PDS ODT using 23 factorial design
| Batches | Factor
|
Response
|
|||
|---|---|---|---|---|---|
| A | B | C | Y1 | Y2 | |
| F1 | −1 | −1 | −1 | 50 | 86.26 |
| F2 | +1 | −1 | +1 | 30 | 91.25 |
| F3 | −1 | +1 | −1 | 60 | 82.33 |
| F4 | +1 | +1 | +1 | 40 | 89.55 |
| F5 | +1 | +1 | −1 | 20 | 93.64 |
| F6 | −1 | +1 | +1 | 80 | 75.20 |
| F7 | −1 | −1 | −1 | 70 | 80.55 |
| F8 | +1 | −1 | +1 | 15 | 98.95 |
Notes: A = CCS concentration (%), B = MCC concentration (%), C = compression force (Ton), Y1 = DT, Y2 = % DR.
Abbreviations: CCS, croscarmellose sodium; DT, disintegration time; DR, in vitro drug release; MCC, microcrystalline cellulose; PDS, prednisolone; ODT, oral dispersible tablets.