Table 3. Epistatic effect of pair-wise interacting factors on the risks of gastric cancer and atrophic gastritis.
| Interacted pair-wise SNPs | Comparison | Subset | GA vs. CON | GC vs. CON | ||
|---|---|---|---|---|---|---|
| OR(95%CI) | P | OR(95%CI) | P | |||
| PGC rs6912200 interacted with PTPN11 rs12229892 | PGC rs6912200 TT/TC vs. CC | PTPN11 rs12229892 GG | 0.65(0.43,0.99) | 0.043 | 0.56(0.35,0.90) | 0.016 |
| PTPN11 rs12229892 AA/GA | 1.32(0.99,1.76) | 0.059 | 1.12(0.83,1.51) | 0.451 | ||
| PTPN11 rs12229892 AA/GA vs. GG | PGC rs6912200 CC | 0.50(0.32,0.79) | 0.003 | 0.59(0.37,0.94) | 0.027 | |
| PGC rs6912200 TT/TC | 1.00(0.77,1.29) | 0.982 | 1.11(0.84,1.46) | 0.466 | ||
| PGC rs4711690 interacted with IL1B rs1143623 | PGC rs4711690 GG/GC vs CC | IL1B rs1143623 GG | 0.81(0.59,1.10) | 0.176 | 1.07(0.77,1.50) | 0.683 |
| IL1B rs1143623 GC/CC | 0.76(0.60,0.96) | 0.021 | 0.69(0.53,0.90) | 0.006 | ||
| IL1B rs1143623 GC/CC vs GG | PGC rs4711690 CC | 1.05(0.82,1.35) | 0.690 | 1.18(0.89,2.56) | 0.254 | |
| PGC rs4711690 GG/GC | 0.99(0.73,1.34) | 0.946 | 0.76(0.55,1.06) | 0.102 | ||
| PTPN11 rs12229892 interacted with IL1B rs1143623 | PTPN11 rs12229892 AA/GA vs. GG | IL1B rs1143623 GG | 0.76(0.55,1.07) | 0.114 | 0.74(0.52,1.07) | 0.110 |
| IL1B rs1143623 GC/CC | 1.03(0.80,1.31) | 0.837 | 1.23(0.93,1.62) | 0.153 | ||
| IL1B rs1143623 GC/CC vs GG | PTPN11 rs12229892 GG | 0.84(0.60,1.17) | 0.295 | 0.68(0.47,1.00) | 0.050 | |
| PTPN11 rs12229892 AA/GA | 1.11(0.88,1.41) | 0.369 | 1.14(0.88,1.47) | 0.331 | ||
All tests were adjusted by age, sex and H. pylori infection. Statistically significant associations were highlighted in bold (P values <0.05). Abbreviation: GC, gastric cancer; GA, atrophic gastritis; CON, healthy controls.