Table 5. Cumulative effect of the three interacting factors of PGC rs6912200, PGC rs4711690 and PTPN11 rs12229892 on the risk of atrophic gastritis.
| No. of interacting genotypes | Total population | H. pylori-negative subpopulation | H. pylori-positive subpopulation | Pbdc | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Controls/cases | OR(95%CI) | Pa | Controls/cases | OR(95%CI) | Pb | Controls/cases | OR(95%CI) | Pb | ||
| 0 | 22/26 | 1(ref) | 14/17 | 8/9 | ||||||
| 1 | 214/222 | 0.76(0.40,1.43) | 0.394 | 154/99 | 0.51(0.24,1.08) | 0.078 | 60/126 | 1.87(0.68,5.15) | 0.226 | 0.049 |
| 2 | 474/376 | 0.56(0.30,1.04) | 0.068 | 342/152 | 0.35(0.17,0.72) | 0.005 | 132/224 | 1.60(0.60,4.29) | 0.353 | 0.020 |
| 3 | 169/140 | 0.54(0.28,1.03) | 0.062 | 121/37 | 0.24(0.11,0.54) | 4.96×10−4 | 48/103 | 2.02(0.73,5.63) | 0.179 | 0.001 |
| P trend=0.005 | ||||||||||
a
, these tests were adjusted by sex, age and H. pylori infection;
b
, these tests were adjusted by sex and age;
c
, Breslow-Day test was employed to assess the homogeneity of stratum-specific ORs between H. pylori-negative and -positive subpopulations. Statistically significant results were highlighted in bold (P values <0.05). Abbreviation: GC, gastric cancer; GA, atrophic gastritis; CON, healthy controls.