Table 2. Blastic plasmacytoid dendritic cell neoplasms classified according to their maturation-associated immunophenotypic profile: laboratory parameters.
| Blast cell phenotype | ||||||
|---|---|---|---|---|---|---|
| Laboratory parameters | Total cases | Group 1 (immature) | Group 2 (intermediate) | Group 3 (mature) | P-value | |
| n = 46 | n = 8 | n = 24 | n = 14 | |||
| Anemia (< 100 g/l) | 28/44 (64%) | 6/7 (86%) | 16/24 (67%) | 6/13 (46%) | NS | |
| Leukopenia (< 4 × 109/l) | 13/43 (30%) | 4/7 (57%) | 8/23 (35%) | 1/13 (8%) | .03a | |
| Neutropenia (< 1.5 × 109/l) | 20/41 (49%) | 6/7 (86%) | 12/22 (55%) | 2/12 (17%) | ≤ .04a, b | |
| Thrombocytopenia (< 100 × 109/l) | 28/43 (65%) | 3/7 (43%) | 16/24 (65%) | 9/12 (75%) | NS | |
| Leukocytosis (> 10 × 109/l) | 14/43 (33%) | 0/7 (0%) | 6/23 (26%) | 8/13 (62%) | ≤ .04a, b | |
| Elevated LDH (≥ 450 U/l) | 22/40 (55%) | 1/6 (17%) | 11/21 (52%) | 10/13 (77%) | .02a | |
| Presence of blast cells (by morphology) | ||||||
| Peripheral blood | % cases | 27/44 (61%) | 4/7 (57%) | 14/24 (58%) | 9/13 (69%) | NS |
| % blast cells1* | 39% (2%–83%) | 11% (2%–35%) | 45% (2%–80%) | 39% (10%–83%) | NS | |
| Bone marrow | % cases | 41/44 (93%) | 8/8 (100%) | 21/24 (88%) | 12/12 (100%) | NS |
| % blast cells1* | 78% (4%–100%) | 68% (46%–73%) | 80% (18%–99%) | 85% (4%–100%) | NS | |
Results expressed as number of cases from all cases with available data (percentage) or as *median (range). Statistically significantly differences were found between agroup 1 group 3 and bgroup 2 group 3. 1Only in cases with blast cells. NS: no statistically significant differences (p > 0.05) found, LDH: lactate dehydrogenase; β2-microg: β2-microglobulin. No statistical differences were observed among the groups regarding creatinine and C-reactive protein levels.