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. 2015 Jul 30;6(22):19228–19245. doi: 10.18632/oncotarget.4653

Figure 8. Diagram describing the mechanism of how DCA efficacy depends on p53 status.

Figure 8

A. DCA activates AMPK/p53 pathway in response to oxidative stress. Wt p53 is phosphorylated and transcriptional activated by AMPKα leading to G1 cell cycle arrest and inhibition of glycolysis. p53 also increases AMPKβ gene expression, reinforcing the AMP-activated protein kinase (AMPK) response. B. DCA doesn't stop proliferation in absence of p53 or presence or mtp53. mtp53 gain of functions could be involved in tumour progression, drug resistance and inhibition of certain genes such as AMPK.