Table 4. HNSCC-associated changes in the serum levels of YRNA-derived small RNAs.
| YRNA1 | YRNA end2 | Genomic coordinates | CPM3 | FC4 | Pvalue4 | FDR4 |
|---|---|---|---|---|---|---|
| RNY1 | 5′ | chr7:148684228-148684340 | 18001.3 | 4.2 | 2.70E-30 | 1.24E-20 |
| RNY4P17 | 5′ | chr4:169926400-169926495 | 198.7 | 2.5 | 1.34E-08 | 1.80E-08 |
| RNY4P1 | 3′ | chr9:77462422-77462517 | 4402.8 | −2.1 | 4.57E-05 | 3.20E-06 |
| RNY4P5 | 3′ | chr8:124056957-124057052 | 4564.0 | −2.1 | 3.08E-05 | 3.08E-06 |
| RNY4P8 | 3′ | chr17:38399475-38399571 | 4059.5 | −2.2 | 4.93E-05 | 1.77E-06 |
| RNY4P11 | 3′ | chr20:18309650-18309746 | 4163.5 | −2.2 | 3.52E-05 | 1.62E-06 |
| Y_RNA.725 | 3′ | chr9:72926523-72926617 | 198.5 | −2.4 | 7.15E-08 | 5.96E-08 |
| Y_RNA.122 | 5′ | chr17:41149933-41150024 | 139.4 | −2.5 | 2.54E-22 | 7.75E-08 |
| RNY4P20 | 5′ | chr6:151619976-151620068 | 1896.0 | −2.5 | 3.61E-31 | 6.21E-09 |
| RNY4P25 | 3′ | chr1:151411476-151411571 | 407.5 | −2.5 | 2.84E-07 | 9.28E-09 |
| RNY4P27 | 5′ | chr13:95988360-95988455 | 1290.9 | −2.7 | 6.58E-29 | 2.75E-10 |
| Y_RNA.182 | 3′ | chr11:33025796-33025891 | 2049.6 | −2.7 | 2.16E-07 | 1.59E-10 |
| Y_RNA.257 | 3′ | chr11:3685045-3685141 | 1575.3 | −2.8 | 8.02E-08 | 5.43E-11 |
| RNY4P18 | 3′ | chr9:113859605-113859693 | 181.9 | −2.8 | 2.14E-09 | 1.59E-10 |
| Y_RNA.44 | 5′ | chr22:41461558-41461650 | 195.9 | −7.1 | 1.89E-82 | 1.42E-31 |
| RNY4P6 | 5′ | chr11:116886613-116886708 | 772.2 | −7.2 | 8.69E-39 | 3.72E-35 |
| Y_RNA.668 | 5′ | chr11:118841208-118841305 | 216.4 | −7.6 | 2.84E-85 | 1.79E-34 |
| Y_RNA.7 | 5′ | chr15:26063130-26063217 | 548.3 | −10.8 | 1.45E-105 | 4.77E-48 |
| Y_RNA.796 | 5′ | chr2:201727875-201727970 | 536.7 | −16.5 | 4.33E-114 | 1.74E-61 |
| Y_RNA.292 | 3′ | chr10:90345395-90345490 | 266.3 | −100.3 | 1.39E-98 | 1.88E-106 |
| Y_RNA.662 | 3′ | chr2:122360649-122360740 | 153.7 | −129.1 | 5.13E-90 | 4.09E-91 |
1
YRNA identity with corresponding genomic positions in the human hg19 genome.
2
Indicates whether the sequencing reads map to the 5′ or 3′ end of YRNAs.
3
Average YRNA read counts-per-million computed over all libraries and taking into account the estimated dispersions and the libraries sizes. It represents a measure of the overall expression level of the YRNA fragments.
4
Fold change, Pvalue and FDR for differential abundance were computed by EdgeR from pairwise comparisons for each YRNA fragment between the control and cancer groups.