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. Author manuscript; available in PMC: 2015 Nov 27.
Published in final edited form as: Cancer Res. 2014 Feb 13;74(7):2073–2081. doi: 10.1158/0008-5472.CAN-13-2993

Figure 6. IGRT caused tumor regression and decreased bioluminescence.

Figure 6

(A) IGRT planning for KHR mice bearing oral tumors. First, a cone beam CT scan was obtained. Then radiation beam angles were designed in order to generate a dosimetry plan. Red dose cloud represented the 100% isodose cloud. (B) 14d old primary tumors regressed after treatment with 20 Gy. Error bars represent ± 1 standard deviation. Results were representative of three similar experiments using 2–5 mice per group. Arrow indicates IGRT (XRT) treatment. Significant differences between unirradiated or irradiated KHR mice were denoted by * for P < .001. (C) 6d after irradiation, oral tumors displayed lower bioluminescence levels. (D) Quantitation of bioluminescence in KHR mice bearing oral tumors receiving 20 Gy (n=3) or non-irradiated mice (n=3). Results were representative of 2 separate experiments.