Table 3.
Univariate analysis of outcomes in black and white patients n = 602
| Hazard Ratio (95% CI)
|
||||
|---|---|---|---|---|
| Locoregional Control | Freedom from Distant Metastasis | Progression Free Survival | Overall Survival | |
| Black | 0.72 (0.54 – 0.96) | 1.32 (0.87 – 2.03) | 0.89 (0.79 – 1.12) | 1.21 (0.87 – 1.69) |
| P value | .03 | .19 | .32 | .24 |
| KPS ≥ 70 | 0.75 (0.42 – 1.53) | 1.00 (0.42 – 3.28) | 0.62 (0.40 – 1.05) | 0.52 (0.29 – 1.03) |
| P value | .40 | .99 | .07 | .06 |
| High-very high comorbidity | 0.98 (0.89 – 1.43) | 0.79 (0.48 – 1.32) | 0.97 (0.74 – 1.24) | 1.0 (0.71 – 1.41) |
| P value | .89 | .31 | .79 | .97 |
| Advanced stage (III – IV) | 1.42 (0.96 – 2.18) | 5.11 × 109 (12.8 – ?) | 1.98 (1.40 – 2.90) | 2.78 (1.67 – 5.05) |
| P value | .08 | <.0001 | <.0001 | <.0001 |
| Income ≤ $35,000 | 0.99 (0.74 – 1.32) | 1.10 (0.75 – 1.65) | 1.04 (0.84 – 1.32) | 1.12 (0.83 – 1.53) |
| P value | .92 | .60 | .68 | .45 |
| Lives with others | 1.0 (0.72 – 1.39) | 1.14 (0.93 – 2.32) | 1.00 (0.78 – 1.30) | 1.09 (0.78 – 1.53) |
| P value | .99 | .11 | .96 | .63 |
| Primary site (Oropharynx referent) | ||||
| Hypopharynx | 0.88 (0.46 – 1.60) | 1.87 (0.96 – 3.56) | 1.22 (0.78 – 1.85) | 1.45 (0.84 – 2.45) |
| Larynx | 1.06 (0.70 – 1.61) | 0.95 (0.53 – 1.69) | 0.97 (0.70 – 1.34) | 0.86 (0.56 – 1.32) |
| Oral cavity | 1.43 (0.95 – 2.57) | 1.24 (0.70 – 2.21) | 1.30 (0.94 – 1.80) | 1.09 (0.70 – 1.69) |
| Other | 1.55 (0.94 – 2.52) | 1.56 (0.78 – 3.00) | 1.56 (1.05 – 2.27) | 1.51 (0.91 – 2.47) |
| P value | .15 | .19 | .07 | .15 |
| ≥ 2 alcoholic drinks/day | 1.49 (1.01 – 2.27) | 2.76 (1.53 – 5.49) | 1.44 (1.07 – 1.99) | 2.07 (1.33 – 3.40) |
| P value | .04 | .0004 | .02 | .0009 |
| > 10 pack-years smoking | 1.16 (0.48 – 1.83) | 0.95 (0.57 – 1.67) | 1.14 (0.82 – 1.62) | 1.77 (1.09 – 3.10) |
| P value | .48 | .84 | .43 | .02 |
| Illicit drug use | 1.21 (0.79 – 1.78) | 1.15 (0.64 – 1.93) | 1.17 (0.84 – 1.60) | 1.31 (0.84 – 1.95) |
| P value | .36 | .62 | .33 | .21 |
| Node IV/V/SCV involved | 1.31 (0.90 – 1.85) | 2.27 (1.47 – 3.44) | 1.58 (1.20 – 2.05) | 1.97 (1.38 – 2.76) |
| P value | .15 | .0003 | .001 | .0003 |
| Postoperative RT | 0.53 (0.37 – 0.73) | 0.76 (0.50 – 1.15) | 0.64 (0.50 – 0.82) | 0.68 (0.48 – 0.94) |
| P value | .0001 | .20 | .0003 | .02 |
| RT delay >5 days | 1.48 (1.06 – 2.03) | 0.96 (0.59 – 1.52) | 1.39 (1.07 – 1.78) | 1.49 (1.06 – 2.08) |
| P value | .02 | .89 | .01 | .02 |
| Truncated RT Course | 4.16 (2.39 – 6.75) | 3.71 (1.56 – 7.44) | 3.70 (2.34 – 5.55) | 4.52 (2.53 – 7.50) |
| P value | <.0001 | .005 | <.0001 | <.0001 |
| Intensity modulated RT | 1.24 (0.92–1.67) | 1.21 (0.81 – 1.79) | 1.42 (1.12 – 1.80) | 1.48 (1.07 – 2.03) |
| P value | .15 | .35 | .004 | .02 |
| Era of RT (1990–97 referent) | ||||
| 1998–2004 | 1.28 (0.86 – 1.93) | 2.35 (1.33 – 4.49) | 1.44 (1.06 – 2.00) | 1.46 (0.96 – 2.28) |
| P value | .23 | .003 | .02 | .07 |
| 2005–2012 | 1.54 (1.02 – 2.39) | 2.23 (1.18 – 4.45) | 2.07 (1.47 – 2.94) | 2.15 (1.36 – 3.47) |
| P value | .04 | .01 | < .0001 | .0009 |
KPS = Karnofsky performance status.
SCV = supraclavicular fossa.
RT = radiotherapy.