. Author manuscript; available in PMC: 2015 Dec 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2015 Nov 6;289(3):428–441. doi: 10.1016/j.taap.2015.10.017

Table 1.

Key Pharmacokinetic Studies in the Male and Female Rat

	Dose (mg/kg BW)	Route	Sex	Endpoint	Use in Model Development
Kemper, Experiment 1	1.0	Oral	M and F	cumulative dose in urine and feces	calibration
Kemper, Experiment 2	5.0	Oral	M and F	cumulative dose in urine and feces	evaluation
Kemper, Experiment 3	25.0	Oral	M and F	cumulative dose in urine and feces	evaluation
Kemper, Experiment 5	0.1	Oral	M and F	serum concentration	evaluation
Kemper, Experiment 6a	1.0	Oral	M and F	serum concentration	calibration
Kemper, Experiment 6b	1.0	IV	M and F	serum concentration	calibration (M), evaluation (F)
Kemper, Experiment 7	5.0	Oral	M and F	serum concentration	evaluation
Kemper, Experiment 8	25.0	Oral	M and F	serum concentration	evaluation
Kudo, Experiment 1	0.041	IV	M	serum and liver concentration	evaluation
Kudo, Experiment 2	16.56	IV	M	serum and liver concentration	evaluation