. Author manuscript; available in PMC: 2015 Dec 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2015 Nov 6;289(3):428–441. doi: 10.1016/j.taap.2015.10.017

Table 4.

Initial and Calibrated Parameter Values

Parameter	Units	Initial Value	Source of Initial Value	Calibrated Value
Free	unitless	0.006	Loccisano, 2012	0.09
RAFapi, male	unitless	0.01356	Yamada, 2007	35
RAFapi, female	unitless	0.01356	Yamada, 2007	0.001356
RAFbaso, male	unitless	0.01356	Yamada, 2007	4.07
RAFbaso, female	unitless	0.01356	Yamada, 2007	0.01356
k0c	/hr/kg^0.25	1.0	-	1.0
Kabsc	/hr/kg^0.25	31.3	Loccisano, 2012	2.12
kunabsc	/hr/kg^0.25	0.001	Loccisano, 2012	7.06 × 10⁻⁵
keffluxc	/hr/kg^0.25	0	-	2.49
Kbilec	/hr/kg^0.25	0.35	Loccisano, 2012	0.004
Kurinec	/hr/kg^0.25	0.1	Loccisano, 2012	1.6