. Author manuscript; available in PMC: 2015 Dec 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2015 Nov 6;289(3):428–441. doi: 10.1016/j.taap.2015.10.017

Table 6.

Sensitive Model Parameters.

	Physiological Parameters	Partition Coefficients	Chemical Specific Model Parameters
Male Rat	BW, GFRC, protein, VfilC, VLC, HTC, QKC, QLC, QCC	PR, PL	kurinec, kbilec, k0c, kabsc, RAFapi, Km_apical, Vmax_apical_invitro, Free, MW
Female Rat	BW, GFRC, protein, VPTCC, VfilC, VLC, VplasC, HTC, QKC, QLC, QCC, MKC	PR, PL	kurinec, kbilec, keffluxc, k0c, kabsc, kdif, RAFapi, Km_apical, Vmax_apical_invitro, Free, MW

Parameters with absolute sensitivity coefficients greater than 1.0 are highlighted in bold.