. Author manuscript; available in PMC: 2016 Dec 15.

Published in final edited form as: Toxicol Appl Pharmacol. 2015 Oct 31;289(3):397–408. doi: 10.1016/j.taap.2015.10.020

Table I.

Effect of As(III) on plasma arginine and metabolite levels

	control	10 μg/L As(III)	250 μg/L As(III)
Arginine metabolic index	0.51 ± 0.03	0.54 ± 0.02	2.64 ± 0.30^*
	Plasma metabolite level (μM, mean ± SEM)
Arginine	85.4 ± 15.7	67.7 ± 7.4	39.6 ± 12.3^*
Citruline	214.6 ± 21.5	225.1 ± 19.4	51.8 ± 6.1^*
Ornithine	368.1 ± 16.7	286.2 ± 16.1^*	185.8 ± 7.4^*^a
SDMA	0.12 ± 0.01	0.13 ± 0.01	0.65 ± 0.09^*
ADMA	0.38 ± 0.01	0.39 ± 0.02	0.85 ± 0.07^*
Monomethylarginine	1.02 ± 0.05	0.96 ±0.04	0.58 ±0.06^*

significant difference from control (p< 0.05, n=5)

significant difference from 10 μg/L As(III) (p< 0.05, n=5)