Table 1.
Laboratory results before, during and after reduction of systemic corticosteroids.
| Test | Before Corticosteroids |
During High Dose Corticosteroids |
After Corticosteroid Reduction |
Normal Values For Age* |
|---|---|---|---|---|
| Lymphocytes (cells/µL) | 5100 | 76 | 1479 | 1800–9000 |
| CD3 (cells/µL) | 788 | 10 | 401 | 2100–6200 |
| CD4 (cells/µL) | ND | 7 | 315 | 1300–3400 |
| CD8 (cells/µL) | ND | 2 | 70 | 620–2000 |
| CD4:CD8 Ratio | 3.7:1 | 2.9:1 | 4.5:1 | 1.2–6.2 |
| CD19 (cells/µL) | 1970 | 51 | 524 | 720–2600 |
| Kappa:Lambda Ratio | 1.3:1 | ND | ND | 1–2 |
| CD16/56 (cells/µL) | ND | 15 | 654 | 180–920 |
| CD4+CD45RO+ (%) | ND | ND | 91.1 | 9.5–41.9% of CD4+ T Cells |
| CD4+CD45RA+ (%) | ND | ND | 7.4 | 16.5–42.2% of CD4+ T Cells |
| CD4+CD45RA+CD31+ (%) | ND | ND | 2.1 | 54.1–75.3 |
| TCR αβ (%) | ND | ND | 94.2 | >85% of CD3+ T Cells |
| CD20+IgD+CD27− (%) | ND | ND | 42 | 83.3–93.7% of CD20+ B Cells |
| CD20+IgD+CD27+ (%) | ND | ND | 32.9 | 3.3–10.8% of CD20+ B Cells |
| CD20+IgD−CD27+ (%) | ND | ND | 18.8 | 1.0–5.0% of CD20+ B Cells |
| IgG (mg/dL) | ND | 505 | ND | 421–120 |
| IgA (mg/dL) | ND | 32 | ND | 15–111 |
| IgM (mg/dL) | ND | 309 | ND | 35–184 |
| IgE (IU/mL) | ND | 50 | ND | 0–49 |
| PHA stimulation | ND | Minimal | ND | - |
| ConA stimulation | ND | Minimal | ND | - |
| PWM stimulation | ND | Minimal | ND | - |
| Tetanus stimulation | ND | None | ND | - |
| Candida stimulation | ND | None | ND | - |
| TLR 1–8 signaling | ND | ND | Normal | - |
*
Assays were performed in different laboratories where normal values may differ.
ND: Not Done