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Genetic strategy for stochastic labeling of c-Kit lineage with one of four possible fluorescent reporters (XFPs). Tamoxifen (TAM)-inducible c-KitCreERT2/+ mice were crossed to the R26R-Confetti reporter, containing the Brainbow 2.1 construct at the R26R locus. Cre recombination leads to removal of the neo transcriptional roadblock, and random recombination leads to expression of one of four possible outcomes: nuclear localized GFP, cytoplasmic RFP or YFP, or membrane associated CFP.
