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. Author manuscript; available in PMC: 2016 Dec 15.
Published in final edited form as: Toxicol Appl Pharmacol. 2015 Oct 28;289(3):457–465. doi: 10.1016/j.taap.2015.10.015

Figure 1. PCB-induced epigenetic regulation of NF-κB subunit p65.

Figure 1

This diagram illustrates the pathways for PCB-induced epigenetic regulation of NF-κB subunit p65. In response to PCBs, ER-α is activated to bind to the EREs in the first intron of JMJD2B and induce its expression. JMJD2B can physically interact with ER-α and MLL2 to form a protein complex and be further recruited to the p65 promoter through AP-1 or Sp1 mediated chromatin binding. This ER-α/JMJD2B/MLL2 complex modifies histone methylation patterns in the promoter region.