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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mucosal Immunol. 2015 May 27;9(1):137–145. doi: 10.1038/mi.2015.45

Figure 6. Lag3 dependent inhibition of T cell activation in the draining lymphoid tissues.

Figure 6

(a) Rag1 −/− mice received CD45.1+ CD4 T cells alone, or together with WT, Il10 −/− , or Lag3 −/− Tregs. T cell expansion and cytokine expression in the mLN were determined 7 days post transfer. (b) Number of Tregs in the mLN. (c) Lag3 expression on WT and Il27ra −/− Tregs. (d) mLN DC (CD11c+ MHCII+) expression of CD86 was determined at 4 days post T cell transfer. Data shown represent the mean ± SD of 3~8 individually tested recipients. *, p<0.05; ***, p<0.001.