Axial images from two participants with Fabry disease (Fabry1, female, 53 years; Fabry2, male, 49 years) and a control participant (female, 59 years). Anatomic structures are identified in f maps for the control participant with representative ROIs (A). In the participants with Fabry disease, there is a substantial reduction in the bound pool fraction (A, white arrow heads). An increase in ADC (B) is present in corresponding anatomic locations. White matter changes in the Fabry participant may be less apparent in the fractional anisotropy (FA) images (C) due to heterogenous fiber direction in some structures such as the posterior white matter (PWM) and corona radiata (CR). In gray matter, particularly the left thalamus, there is evidence of increased restricted anisotropy on FA (C, white arrows) in the Fabry participant. CCG = corpus callosum, genu; CCS = corpus callosum, splenium; FWM = frontal white matter; HC = head of caudate; TH = thalamus