Table 3.

Effects on blood glucose, body weight, and BP in subgroups classified by baseline BP

Dose		Total	SBP		DBP
			<130 mmHg	≥130 mmHg	<80 mmHg	≥80 mmHg
100 mg	HbA1c (%)
	Number of patients	584	295	289	334	250
	Baseline	8.05 [0.88]	8.09 [0.91]	8.01 [0.85]	8.09 [0.93]	8.00 [0.81]
	Week 52	7.11 [0.76]	7.13 [0.71]	7.09 [0.80]	7.11 [0.72]	7.12 [0.81]
	Change from baseline at week 52	−0.94 [0.77]	−0.95 [0.75]	−0.92 [0.79]	−0.98 [0.77]	−0.88 [0.77]
	Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001
	FPG (mg/dL)
	Number of patients	583	295	288	334	249
	Baseline	158.9 [35.3]	157.1 [35.3]	160.8 [35.3]	157.2 [35.9]	161.3 [34.5]
	Week 52	129.3 [27.9]	127.9 [26.6]	130.7 [29.2]	127.4 [26.0]	131.7 [30.2]
	Change from baseline at week 52	−29.7 [34.2]	−29.3 [36.0]	−30.1 [32.4]	−29.8 [35.5]	−29.6 [32.5]
	Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001
	Body weight (kg)
	Number of patients	584	295	289	334	250
	Baseline	70.44 [15.56]	68.80 [15.51]	72.12 [15.46]	66.70 [14.76]	75.45 [15.22]
	Week 52	67.76 [15.35]	66.26 [15.33]	69.29 [15.24]	64.09 [14.65]	72.67 [14.91]
	Change from baseline at week 52	−2.68 [2.51]	−2.54 [2.44]	−2.83 [2.59]	−2.61 [2.31]	−2.78 [2.76]
	Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001
	SBP (mmHg)
	Number of patients	584	295	289	334	250
	Baseline	128.87 [13.10]	118.29 [8.11]	139.67 [6.94]	123.00 [12.27]	136.73 [9.58]
	Week 52	124.11 [13.01]	117.51 [11.24]	130.84 [11.11]	119.80 [12.38]	129.86 [11.54]
	Change from baseline at week 52	−4.76 [11.43]	−0.78 [10.25]	−8.83 [11.14]	−3.19 [11.10]	−6.86 [11.53]
	Paired t test	<0.001	0.192	<0.001	<0.001	<0.001
	DBP (mmHg)
	Number of patients	584	295	289	334	250
	Baseline	77.76 [9.60]	73.07 [8.41]	82.54 [8.30]	71.18 [6.55]	86.54 [4.79]
	Week 52	74.89 [9.87]	72.30 [9.36]	77.52 [9.69]	70.22 [8.44]	81.11 [8.04]
	Change from baseline at week 52	−2.87 [7.49]	−0.77 [7.43]	−5.02 [6.92]	−0.96 [7.06]	−5.43 [7.30]
	Paired t test	<0.001	0.077	<0.001	0.013	<0.001
200 mg	HbA1c (%)
	Number of patients	713	377	336	394	319
	Baseline	8.09 [0.86]	8.08 [0.87]	8.10 [0.86]	8.04 [0.86]	8.15 [0.87]
	Week 52	7.04 [0.69]	7.00 [0.67]	7.09 [0.72]	7.01 [0.67]	7.08 [0.72]
	Change from baseline at week 52	−1.05 [0.76]	−1.08 [0.72]	−1.01 [0.80]	−1.03 [0.75]	−1.07 [0.78]
	Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001
	FPG (mg/dL)
	Number of patients	711	376	335	393	318
	Baseline	158.9 [34.4]	161.1 [35.9]	156.5 [32.6]	157.2 [34.9]	161.0 [33.8]
	Week 52	124.9 [22.6]	123.8 [21.5]	126.2 [23.7]	122.5 [20.5]	128.0 [24.6]
	Change from baseline at week 52	−34.0 [30.7]	−37.3 [29.9]	−30.3 [31.3]	−34.8 [29.8]	−33.0 [31.8]
	Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001
	Body weight (kg)
	Number of patients	713	377	336	394	319
	Baseline	69.73 [14.66]	69.02 [15.02]	70.53 [14.22]	66.30 [13.65]	73.97 [14.77]
	Week 52	66.66 [14.34]	65.87 [14.49]	67.56 [14.13]	63.20 [13.13]	70.94 [14.63]
	Change from baseline at week 52	−3.07 [2.79]	−3.16 [2.66]	−2.97 [2.92]	−3.10 [2.68]	−3.03 [2.92]
	Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001
	SBP (mmHg)
	Number of patients	713	377	336	394	319
	Baseline	128.48 [13.00]	118.59 [8.44]	139.58 [6.76]	122.43 [12.14]	135.95 [9.76]
	Week 52	122.00 [13.37]	116.51 [11.94]	128.17 [12.15]	117.91 [13.04]	127.05 [11.98]
	Change from baseline at week 52	−6.48 [12.56]	−2.09 [10.83]	−11.41 [12.55]	−4.52 [11.95]	−8.91 [12.89]
	Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001
	DBP (mmHg)
	Number of patients	713	377	336	394	319
	Baseline	77.97 [9.92]	73.59 [8.83]	82.88 [8.70]	70.82 [6.65]	86.79 [4.90]
	Week 52	74.05 [9.76]	71.68 [9.22]	76.72 [9.68]	69.24 [8.15]	80.01 [8.18]
	Change from baseline at week 52	−3.91 [8.11]	−1.91 [7.26]	−6.16 [8.42]	−1.58 [7.26]	−6.79 [8.19]
	Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001

Missing data at week 52 were imputed using last observation carried forward method. Data are shown as mean [standard deviation]

DBP diastolic blood pressure, FPG fasting plasma glucose, HbA1c hemoglobin A1c, SBP systolic blood pressure