Table 5.

Effects on blood glucose, body weight, and lipids in subgroups classified by baseline LDL-C

Dose	100 mg			200 mg
	Total	LDL-C		Total	LDL-C
		<120 mg/dL	≥120 mg/dL		<120 mg/dL	≥120 mg/dL
HbA1c (%)
Number of patients	584	296	288	713	345	368
Baseline	8.05 [0.88]	8.04 [0.89]	8.06 [0.87]	8.09 [0.86]	8.06 [0.85]	8.12 [0.88]
Week 52	7.11 [0.76]	7.07 [0.71]	7.16 [0.80]	7.04 [0.69]	7.03 [0.71]	7.06 [0.69]
Change from baseline at week 52	−0.94 [0.77]	−0.97 [0.76]	−0.90 [0.78]	−1.05 [0.76]	−1.03 [0.78]	−1.07 [0.75]
Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
FPG (mg/dL)
Number of patients	583	295	288	711	343	368
Baseline	158.9 [35.3]	156.4 [34.0]	161.5 [36.6]	158.9 [34.4]	157.2 [32.7]	160.5 [35.9]
Week 52	129.3 [27.9]	127.6 [21.7]	131.0 [33.1]	124.9 [22.6]	124.6 [23.9]	125.3 [21.3]
Change from baseline at week 52	−29.7 [34.2]	−28.8 [29.1]	−30.6 [38.9]	−34.0 [30.7]	−32.6 [31.3]	−35.3 [30.1]
Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
Body weight (kg)
Number of patients	584	296	288	713	345	368
Baseline	70.44 [15.56]	69.75 [15.74]	71.16 [15.37]	69.73 [14.66]	69.44 [14.94]	70.00 [14.40]
Week 52	67.76 [15.35]	67.17 [15.56]	68.37 [15.13]	66.66 [14.34]	66.19 [14.59]	67.11 [14.10]
Change from baseline at week 52	−2.68 [2.51]	−2.58 [2.57]	−2.79 [2.45]	−3.07 [2.79]	−3.26 [2.66]	−2.89 [2.89]
Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
LDL-C (mg/dL)
Number of patients	584	296	288	713	345	368
Baseline	120.0 [28.8]	97.5 [15.0]	143.2 [19.6]	122.1 [28.7]	99.1 [15.1]	143.6 [20.6]
Week 52	118.9 [27.9]	103.2 [21.4]	134.9 [24.5]	124.1 [30.0]	107.8 [23.8]	139.4 [27.1]
Change from baseline at week 52	−1.2 [22.9]	5.8 [19.7]	−8.3 [23.8]	2.1 [24.0]	8.7 [21.0]	−4.2 [25.0]
Paired t test	0.220	<0.001	<0.001	0.022	<0.001	0.002
HDL-C (mg/dL)
Number of patients	584	296	288	713	345	368
Baseline	53.7 [12.7]	53.8 [13.7]	53.7 [11.8]	53.8 [13.1]	53.9 [14.3]	53.6 [11.9]
Week 52	58.0 [14.4]	58.0 [15.3]	58.0 [13.3]	58.4 [14.6]	59.4 [15.8]	57.5 [13.3]
Change from baseline at week 52	4.3 [7.8]	4.2 [8.6]	4.3 [6.9]	4.7 [7.7]	5.4 [7.8]	3.9 [7.5]
Paired t test	<0.001	<0.001	<0.001	<0.001	<0.001	<0.001
LDL-C/HDL-C
Number of patients	584	296	288	713	345	368
Baseline	2.356 [0.784]	1.926 [0.558]	2.797 [0.736]	2.400 [0.789]	1.965 [0.592]	2.808 [0.732]
Week 52	2.173 [0.779]	1.909 [0.747]	2.445 [0.716]	2.262 [0.794]	1.948 [0.685]	2.556 [0.777]
Change from baseline at week 52	−0.182 [0.567]	−0.017 [0.578]	−0.352 [0.502]	−0.138 [0.500]	−0.017 [0.408]	−0.252 [0.550]
Paired t test	<0.001	0.613	<0.001	<0.001	0.441	<0.001
Triglyceride (mg/dL)
Number of patients	583	295	288	711	343	368
Baseline	143.6 [94.4]	144.2 [107.7]	142.9 [78.8]	152.4 [105.8]	153.0 [125.1]	151.9 [84.0]
Week 52	131.9 [106.3]	137.4 [126.0]	126.2 [81.1]	130.7 [95.0]	128.6 [96.2]	132.6 [93.9]
Change from baseline at week 52	−11.7 [103.7]	−6.9 [121.8]	−16.7 [81.0]	−21.7 [96.8]	−24.4 [105.8]	−19.3 [87.7]
Paired t test	0.007	0.335	<0.001	<0.001	<0.001	<0.001

Missing data at week 52 were imputed using last observation carried forward method. Data were shown as mean [standard deviation]

FPG fasting plasma glucose, HbA1c hemoglobin A1c, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol