Table 2.
Association of HLA-B amino-acid haplotype with susceptibility to ankylosing spondylitis
| Amino-acid haplotype | Haplotype frequency | Association for AS | ||||
|---|---|---|---|---|---|---|
| 70 | 97 | 114 | Cases | Controls | OR (95 % CI) | P value |
| Lys | Asn | His | 0.482 | 0.025 | 243.0 (172.4–342.4) | 2.70 × 10−216 |
| Asn | Ser | Asn | 0.064 | 0.087 | 0.72 (0.56–0.91) | 6.38 × 10−3 |
| Gln | Ser | Asp | 0.024 | 0.038 | 0.65 (0.45–0.95) | 2.55 × 10−2 |
| Asn | Arg | Asn | 0.064 | 0.103 | 0.59 (0.47–0.75) | 1.49 × 10−5 |
| Gln | Thr | Asn | 0.042 | 0.069 | 0.58 (0.44–0.78) | 2.77 × 10−4 |
| Gln | Arg | Asp | 0.024 | 0.044 | 0.54 (0.37–0.79) | 1.24 × 10−3 |
| Asn | Thr | Asn | 0.121 | 0.217 | 0.48 (0.40–0.58) | 2.02 × 10−15 |
| Ser | Arg | Asp | 0.031 | 0.065 | 0.46 (0.33–0.64) | 3.70 × 10−6 |
| Asn | Arg | Asp | 0.141 | 0.319 | 0.35 (0.30–0.42) | 2.74 × 10−34 |
| Asn | Trp | Asn | 0.004 | 0.014 | 0.27 (0.11–0.66) | 4.34 × 10−3 |
| Asn | Ser | Asp | 0.001 | 0.012 | 0.06 (0.01–0.44) | 5.69 × 10−3 |
HLA human leukocyte antigen, AS ankylosing spondylitis, OR odds ratio, CI confidence interval
*Each of the HLA-B classic alleles observed in the Korean subjects belongs to one of the amino-acid haplotypes. Lys-Asn-His: *27:04, *27:05; Asn-Ser-Asn: *08:01, *40:02, *48:01; Gln-Ser-Asp: *07:02; Asn-Arg-Asn: *13:01, *37:01, *38:02, *39:01, *40:01, *51:06; Gln-Thr-Asn: *54:01, *55:01, *55:02, *56:01, *56:05; Gln-Arg-Asp: *46:01; Asn-Thr-Asn: *13:02, *40:06, *51:01, *51:02, *52:01, *59:01; Ser-Arg-Asp: *58:01; Asn-Arg-Asp: *15:01, *15:02, *15:11, *15:18, *15:27, *15:38, *18:01, *35:01, *35:03, *44:02, *44:03; Asn-Trp-Asn: *14:01; Asn-Ser-Asp: *15:07, *40:03