Table 5.
Chromosome structure genes showing DE upon FL exposure. Shaded boxes are up-regulated while down-regulated are unshaded. np = not significant for that exposure.
| Ensembl I.D | Gene | Fold Change | Description | ||
|---|---|---|---|---|---|
| 20 | 40 | 60 | |||
| ENSXMAT00000006097 | aurka | np | −3.56 | −3.87 | aurora kinase A, ser/thr kinase important for cell cycle progression and p53 |
| ENSXMAT00000000581 | cdca7b | −2.77 | −2.42 | −2.04 | cell division cycle associated 7b |
| ENSXMAT00000004312 | cdkn1d | 2.23 | 2.18 | 2.14 | cyclin-dependent kinase inhibitor 1D, Circadian regulator |
| ENSXMAT00000010065 | cenpe | −2.71 | −4.45 | −2.87 | centromere protein E, Kinetochore, chromosome alignment and movement |
| ENSXMAT00000015178 | cenpf | −2.76 | −4.41 | −3.27 | centromere protein F, (mitosin), Centromere at G2, localizes to spindle in anaphase & telophase |
| ENSXMAT00000007642 | chtf18 | −2.09 | −2.55 | np | CTF18, chromosome transmission fidelity factor 1, Chromosome cohesion, S phase |
| ENSXMAT00000000722 | depdc1a | −3.04 | −4.58 | −4.26 | DEP domain containing 1a, represses A20 leading to transport of NF-Kβ |
| ENSXMAT00000002159 | espl1 | −3.00 | −4.42 | −3.27 | extra spindle poles like 1, Mitotic spindle function |
| ENSXMAT00000018919 | haus5 | −2.92 | −3.16 | np | HAUS augmin-like complex, subunit 5, Involved in mitotic spindle, vital to spindle assembly |
| ENSXMAT00000003800 | kif18a | −2.48 | −3.05 | np | kinesin family member 18A, Kinetochore function, regulates CENPE |
| ENSXMAT00000003706 | kif23 | −2.58 | −3.70 | −2.71 | kinesin family member 23, Chromosome movement, spindle, cytokinesis |
| ENSXMAT00000016886 | kifc1 | np | −3.96 | −3.26 | kinesin family member 2C, Important role in cytokinesis, spindle |
| ENSXMAT00000009865 | ncapg | np | −3.54 | −3.11 | non-SMC condensin II complex, subunit D3, condensation of chromosomes during mitosis |
| ENSXMAT00000017114 | ndc80 | −2.29 | −2.40 | −2.10 | NDC80 homolog, kinetochore complex component, Kinetochore, chromosome segregation |
| ENSXMAT00000015146 | pask | −2.53 | −2.78 | −2.21 | PAS domain ser/threo kinase, Regulates changing environmental conditions, energy homeostasis |
| ENSXMAT00000006913 | prc1a | np | −3.44 | −3.49 | protein regulator of cytokinesis 1a |
| ENSXMAT00000018132 | prc1b | −2.90 | −4.04 | −3.91 | protein regulator of cytokinesis 1b |
| ENSXMAT00000013737 | pttg1 | −2.20 | np | −2.34 | pituitary tumor-transforming 1, Chromosome stability, DNA repair, negatively regulates p53 |
| ENSXMAT00000004597 | smc2 | −2.58 | −3.11 | −2.38 | structural maintenance of chromosomes 2, Critical for mitotic condensation and DNA repair |
| ENSXMAT00000019592 | sox3 | 2.96 | 2.33 | 3.38 | SRY-box containing gene 3 |
| ENSXMAT00000010119 | spag5 | −2.81 | −3.57 | −3.20 | sperm associated antigen 5, Functions at spindle, chrom. segregation, anaphase progression |
| ENSXMAT00000013574 | tacc3 | −2.51 | −2.92 | −3.02 | transforming, acidic coiled-coil containing protein 3, Stabilization of the mitotic spindle |
| ENSXMAT00000007097 | ttk | np | −3.34 | −2.98 | ttk protein kinase, centrosome alignment, mitotic segregation |
| ENSXMAT00000015815 | ybx2 | 3.59 | 2.91 | 3.81 | Y box binding protein 2, transcription factor and RNA binding |