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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Semin Cell Dev Biol. 2015 May 28;43:66–75. doi: 10.1016/j.semcdb.2015.05.008

Figure 1. Multigenerational vs. transgenerational effects transmitted through the F0 female vs. F0 male.

Figure 1

Exposure of a pregnant F0 dam directly exposes both the F1 (exposed as developing fetus) and F2 (exposed as developing germ cells of F1) generations. The first generation to experience no direct exposure to the original stimulus (lightning bolt) from maternal exposure is the F3 generation. Paternal F0 exposure directly exposes the F1 generation only (exposed as germ cells). Effects observed in the F2 generation are, therefore, considered transgenerational.