Figure 3. Increased expression of repetitive elements and incidence of DNA double-strand breaks (DSBs) in Hdac1:2−/− oocytes.
(A) Relative abundance of repetitive element mRNA in WT and Hdac1:2−/− growing oocytes obtained from mice 12 days-of-age. Data are expressed relative to that in WT oocytes as mean ± SEM. *, p< 0.05. (B) Immunocytochemical detection of DSBs with anti-γH2AX (green). DNA was detected with propidium iodide (red). Shown are representative images and only the nucleus is shown.